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首页> 外文期刊>Injury >Tolerance of staphylococci to bactericidal antibiotics.
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Tolerance of staphylococci to bactericidal antibiotics.

机译：金黄色葡萄球菌对杀菌抗生素的耐受性。

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摘要

Antibiotic therapy for deep-seated staphylococcal infections, especially when they are associated with artificial devices used for orthopedic surgery is often associated with failure. Standard anti-staphylococcal bactericidal antibiotics, such as semi-synthetic penicillins, cephalosporins, or glycopeptides, are effective when given prophylactically in clinical conditions or experimental trials of implant-related infections. However, the efficacy of all anti-staphylococcal agents is seriously diminished on already established implant-related deep-seated infections, which then frequently require surgical implant removal to obtain a cure. The failure of antibiotic therapy to cure established staphylococcal foreign-body infections may arise in part from a broad-spectrum phenotypic tolerance expressed in vivo to different classes of antimicrobial agents. The molecular and physiological mechanisms of this in vivo tolerance remain poorly understood.
机译：深层葡萄球菌感染的抗生素治疗，尤其是与用于整形外科的人工器械结合时，通常会导致失败。标准的抗葡萄球菌杀菌抗生素，例如半合成青霉素，头孢菌素或糖肽，在临床条件或与植入物相关的感染的实验性试验中进行预防时有效。但是，在已经建立的与植入物有关的深部感染中，所有抗葡萄球菌药物的功效都会严重降低，然后这种感染经常需要手术切除植入物才能治愈。抗生素治疗无法治愈已确定的葡萄球菌异物感染的部分原因可能是体内对不同种类的抗菌剂表达的广谱表型耐受性。这种体内耐受的分子和生理机制仍然知之甚少。

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