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Synaptic interactions in neurones of the rat rostral ventrolateral medulla oblongata.

机译:大鼠延髓腹侧延髓神经元中的突触相互作用。

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摘要

Increasing number of studies indicate that stimulation of peripheral nerves elicits complex postsynaptic responses in neurones of the ventral medulla oblongata. The present study describes a recommended protocol for intracellular recording of complex postsynaptic events in neurones of the ventral medulla oblongata. The aim was to provide surgical and experimental details that will enable successful recording of slow synaptic responses in vivo, in addition to the recording of fast evoked responses. The existence of slow inhibitory responses to stimulation of the cervical vagus and sciatic nerves have already been demonstrated together with the existence of convergent visceral and viscero-somatic inputs to neurones here. The data collected in over 200 neurones so far indicated that neurones of the rostral ventrolateral medulla oblongata play an important and versatile role in the integration of somato-visceral sensory inputs.
机译:越来越多的研究表明,对周围神经的刺激会在腹侧延髓神经元中引起复杂的突触后反应。本研究描述了腹侧延髓神经元中复杂突触后事件的细胞内记录的推荐方案。目的是提供外科手术和实验细节,除了记录快速诱发的反应外,还可以成功记录体内缓慢的突触反应。已经证明存在对宫颈迷走神经和坐骨神经刺激的缓慢抑制反应,以及这里向神经元汇聚的内脏和内体的收敛输入。到目前为止,在200多个神经元中收集到的数据表明,延髓延髓腹侧延髓的神经元在整合体-内脏感觉输入中起着重要而通用的作用。

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