An introduction to induced pluripotent stem cells.

Hanley J; Rastegarlari G; Nathwani AC

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An introduction to induced pluripotent stem cells.

机译：诱导多能干细胞简介。

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Recent landmark studies show that it is now possible to convert somatic cells, such as skin fibroblasts and B lymphocytes, into pluripotent stem cells that closely resemble embryonic stem cells. These induced pluripotent stem (iPS) cells can be generated without using human embryos or oocytes, thus bypassing some of the ethical issues that have limited the use of human embryonic stems (hES) cells. Additionally, they can be derived from the patient to be treated, thereby overcoming problems of immunological rejection associated with the use of allogeneic hES cell derived progenitors. Whilst these patient-specific iPS cells have great clinical potential, their immediate utility is likely to be in drug screening and for understanding the disease process. This review discusses the promise of iPS cells as well as the challenges to their use in the clinic.

机译：最近的标志性研究表明，现在有可能将诸如皮肤成纤维细胞和B淋巴细胞的体细胞转化为与胚胎干细胞非常相似的多能干细胞。这些诱导的多能干（iPS）细胞可以在不使用人类胚胎或卵母细胞的情况下生成，从而绕开了一些限制人类胚胎干（hES）细胞使用的伦理问题。另外，它们可以源自待治疗的患者，从而克服了与使用同种异体hES细胞来源的祖细胞相关的免疫排斥问题。尽管这些患者特异性iPS细胞具有巨大的临床潜力，但它们的直接用途可能是用于药物筛选和了解疾病过程。这篇评论讨论了iPS细胞的前景以及在临床中使用它们的挑战。

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《British Journal of Haematology》 |2010年第1期|共9页
作者
Hanley J; Rastegarlari G; Nathwani AC;
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正文语种 eng
中图分类血液及淋巴系疾病;
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1. An introduction to induced pluripotent stem cells. [J] . Hanley J, Rastegarlari G, Nathwani AC British Journal of Haematology . 2010,第1期

机译：诱导多能干细胞简介。
2. Cyclin A1 is essential for setting the pluripotent state and reducing tumorigenicity of induced pluripotent stem cells. [J] . Samuel McLenachan, Cristina Menchón, Angel Raya, Stem cells and development . 2012,第15期

机译：细胞周期蛋白A1对于设定多能状态和降低诱导的多能干细胞的致瘤性至关重要。
3. Human endometrial cells express elevated levels of pluripotent factors and are more amenable to reprogramming into induced pluripotent stem cells. [J] . Park JH, Daheron L, Kantarci S, Endocrinology . 2011,第3期

机译：人子宫内膜细胞表达高水平的多能性因子，更易于重编程为诱导性多能干细胞。
4. Ile-Lys-Val-Ala-Val and Leu-Arg-Glu peptide signaling in combination with matrix metalloprotease cleavable erosslinkers alter extracellular matrix degrading enzyme expression and axon extension in encapsulated human induced pluripotent stem cell derived neural stem cells. [C] . T. Hiran Perera, Laura A. Smith Callahan Society for Biomaterials annual meeting and exposition . 2019

机译：Ile-Lys-Val-Ala-Val和Leu-Arg-Glu肽信号转导与基质金属蛋白酶可切割的erosslinker结合改变封装的人诱导多能干细胞衍生的神经干细胞中细胞外基质降解酶的表达和轴突延伸。
5. Characterizing inter-individual regulatory variation using induced pluripotent stem cells. [D] . Banovich, Nicholas Eli. 2016

机译：使用诱导的多能干细胞表征个体间的调控差异。
6. Efficient introduction of an isogenic homozygous mutation to induced pluripotent stem cells from a hereditary hearing loss family using CRISPR/Cas9 and single-stranded donor oligonucleotides [O] . Yunpeng Dong, Tao Peng, Weijing Wu, 2019

机译：使用CRISPR / Cas9和单链供体寡核苷酸将等基因纯合突变有效引入遗传性听力损失家族的诱导多能干细胞
7. A quantitative system for discriminating induced pluripotent stem cells, embryonic stem cells and somatic cells. [O] . Anyou Wang, Ying Du, Qianchuan He, 2013

机译：用于区分诱导多能干细胞，胚胎干细胞和体细胞的定量系统。

An introduction to induced pluripotent stem cells.

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