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首页> 外文期刊>British Journal of Haematology >Risk of progression in smouldering myeloma and monoclonal gammopathies of unknown significance: comparative analysis of the evolution of monoclonal component and multiparameter flow cytometry of bone marrow plasma cells.
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Risk of progression in smouldering myeloma and monoclonal gammopathies of unknown significance: comparative analysis of the evolution of monoclonal component and multiparameter flow cytometry of bone marrow plasma cells.

机译：阴燃性骨髓瘤和单克隆血友病病情进展的未知危险：骨髓浆细胞单克隆成分的进化和多参数流式细胞术的比较分析。

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摘要

The present study explored the impact of two novel criteria; having >95% abnormal plasma cells by flow cytometry at diagnosis and the evolving subtype of the disease, as predictors of progression in 61 smouldering multiple myeloma (SMM) and 311 monoclonal gammopathy of unknown significance (MGUS) patients. Although both criteria were of prognostic value, the risk of progression was better identified by immunophenotyping [Hazard Ratio (HR) 6.2 and 17.2 for SMM and MGUS, respectively] than evolving subtype, which had independent prognostic value only in MGUS (HR 3.6). Immunophenotyping discriminated the different risk of progression within the evolving and non-evolving subgroups of SMM (P = 0.01) and MGUS (P < 0.001).
机译：本研究探讨了两个新标准的影响;通过流式细胞术在诊断时具有> 95％的异常浆细胞以及该疾病的亚型发展，可预测61例闷烧的多发性骨髓瘤（SMM）和311例未知意义的单克隆性丙种球蛋白病（MGUS）患者的进展。尽管这两个标准都具有预后价值，但通过免疫表型[分别对SMM和MGUS的危险比（HR）6.2和17.2]更好地确定了进展的风险，而不是仅在MGUS中具有独立预后价值的进化亚型（HR 3.6）。免疫分型法可区分SMM（P = 0.01）和MGUS（P <0.001）的进化和非进化亚组内不同的进展风险。

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