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首页> 外文期刊>British Journal of Haematology >The effect of rituximab on humoral and cell mediated immunity and infection in the treatment of autoimmune diseases.
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The effect of rituximab on humoral and cell mediated immunity and infection in the treatment of autoimmune diseases.

机译：利妥昔单抗在自身免疫性疾病治疗中对体液和细胞介导的免疫和感染的影响。

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摘要

Depletion of B lymphocytes using the anti-CD20 monoclonal antibody rituximab has wide-spread use in the treatment of patients with autoimmune disorders. As haematopoietic progenitor cells and only a fraction of differentiated plasma express CD20, the effect of rituximab on immune function appears to be minimal. However, hypogammagobulinaemia can occur with repeated doses and emerging data from large studies suggest a subtle increase in the risk of infection. Reactivation of latent JC virus, resulting in progressive multifocal leucoencephalopathy, and hepatitis B virus, resulting in hepatoxicity, have been documented in patients receiving rituximab; although confounding effects of concomitant immunosuppressive therapies and immune dysregulation due to the underlying disease make causal associations of infections problematic. This review discusses the efficacy of B cell depletion therapy in the treatment of autoimmune diseases, the effect of B cell depletion on infection and immunity including the role of the B cell in autoimmunity, and identifies areas of controversy.
机译：使用抗CD20单克隆抗体利妥昔单抗消耗B淋巴细胞已广泛用于治疗自身免疫性疾病的患者。由于造血祖细胞和仅一小部分分化的血浆表达CD20，利妥昔单抗对免疫功能的作用似乎很小。但是，反复用药可能会导致血红蛋白球蛋白血症，大型研究的新数据表明，感染的风险略有增加。在接受利妥昔单抗治疗的患者中，已有文献报道潜在的JC病毒再活化导致进行性多灶性白质脑病，乙型肝炎病毒导致肝毒性。尽管伴随免疫抑制疗法和由于潜在疾病引起的免疫失调的混杂效应使感染的因果关系成为问题。这篇综述讨论了B细胞耗竭疗法在自身免疫疾病治疗中的功效，B细胞耗竭对感染和免疫的影响，包括B细胞在自身免疫中的作用，并确定了有争议的领域。

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