• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Brain research. Brain research protocols >Learned helplessness: validity and reliability of depressive-like states in mice.
【24h】

Learned helplessness: validity and reliability of depressive-like states in mice.

机译：习得性无助：小鼠抑郁样状态的有效性和可靠性。

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The learned helplessness paradigm is a depression model in which animals are exposed to unpredictable and uncontrollable stress, e.g. electroshocks, and subsequently develop coping deficits for aversive but escapable situations (J.B. Overmier, M.E. Seligman, Effects of inescapable shock upon subsequent escape and avoidance responding, J. Comp. Physiol. Psychol. 63 (1967) 28-33 ). It represents a model with good similarity to the symptoms of depression, construct, and predictive validity in rats. Despite an increased need to investigate emotional, in particular depression-like behaviors in transgenic mice, so far only a few studies have been published using the learned helplessness paradigm. One reason may be the fact that-in contrast to rats (B. Vollmayr, F.A. Henn, Learned helplessness in the rat: improvements in validity and reliability, Brain Res. Brain Res. Protoc. 8 (2001) 1-7)--there is no generally accepted learned helplessness protocol available for mice. This prompted us to develop a reliable helplessness procedure in C57BL/6N mice, to exclude possible artifacts, and to establish a protocol, which yields a consistent fraction of helpless mice following the shock exposure. Furthermore, we validated this protocol pharmacologically using the tricyclic antidepressant imipramine. Here, we present a mouse model with good face and predictive validity that can be used for transgenic, behavioral, and pharmacological studies.
机译：习得的无助模式是一种抑郁模型，在这种模型中，动物面临不可预测和不可控制的压力，例如压力。电击，随后在厌恶但可逃避的情况下发展应对缺陷（J.B.Overmier，M.E。塞利格曼，不可避免的电击对随后逃避和避免反应的影响，J.Comp.Physiol.Psychol.63（1967）28-33）。它代表了与大鼠抑郁，构造和预测效度的症状非常相似的模型。尽管越来越需要研究转基因小鼠的情绪，尤其是抑郁样行为，但迄今为止，仅使用学习型无助模式发表了几项研究。一个原因可能是这样的事实，与大鼠相反（B.Vollmayr，FA Henn，学习到大鼠的无助：有效性和可靠性的提高，Brain Res.Brain Res.Protoc.8（2001）1-7）-没有可用于小鼠的普遍接受的学习无助协议。这促使我们在C57BL / 6N小鼠中开发一种可靠的无助程序，排除可能的伪影，并建立一个方案，在电击暴露后产生一致比例的无助小鼠。此外，我们使用三环抗抑郁药丙咪嗪药理学验证了该方案。在这里，我们提出了一种具有良好面部表情和预测有效性的小鼠模型，可用于转基因，行为和药理研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号