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首页> 外文期刊>Brain research. Brain research protocols >Electrocorticographic and deep intracerebral EEG recording in mice using a telemetry system.
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Electrocorticographic and deep intracerebral EEG recording in mice using a telemetry system.

机译：使用遥测系统在小鼠体内进行脑电记录和深层脑电图记录。

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Telemetric EEG recording plays a crucial role in the neurological characterization of various transgenic mouse models giving valuable information about epilepsies and sleep disorders in humans. In the past different experimental approaches have been described using tethered systems and jacket systems containing recorders. A main disadvantage of these is their sometimes unphysiological, restraining character. Telemetric EEG recording overcomes most of these disadvantages and allows precise and highly sensitive measurement under various physiological and pathophysiological conditions and different stages of consciousness, as during seizure activity and different sleep stages. Here we present the first contiguous, detailed description of a successful and quick technique for intraperitoneal implantation or subcutaneous pouch implantation of a radiofrequency transmitter in mice and subsequent lead placement in both epidural and deep intracerebral position. Preoperative preparation of the mice, suitable anesthesia, as well as postoperative treatment including pain management are described in detail to provide optimal postoperative recovery. Finally, we display examples of electrocorticograms and deep intracerebral recordings, present strategies to maximize signal-to-noise ratio, paying special attention to major pitfalls and possible artefacts occurring in telemetric EEG recording in mice.
机译：遥测脑电图记录在各种转基因小鼠模型的神经学表征中起着至关重要的作用，这些模型可提供有关人类癫痫和睡眠障碍的宝贵信息。在过去，已经描述了使用系留系统和包含记录器的外套系统的不同实验方法。这些的主要缺点是它们有时缺乏生理学的约束特性。遥测脑电图记录克服了这些缺点中的大多数，并允许在各种生理和病理生理条件下以及意识的不同阶段（如癫痫发作和不同睡眠阶段）进行精确而高度敏感的测量。在这里，我们介绍成功和快速的技术的首次连续，详细的描述，该技术用于在小鼠中腹膜内植入或皮下囊袋内植入射频发射器，以及随后在硬膜外和深层脑内放置导线。详细描述了小鼠的术前准备，适当的麻醉以及包括疼痛管理在内的术后治疗，以提供最佳的术后恢复。最后，我们展示了脑电图和脑内深层记录的示例，介绍了最大化信噪比的策略，并特别注意了老鼠在遥测EEG记录中出现的重大陷阱和可能出现的伪影。

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