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首页> 外文期刊>Brain research. Brain research protocols >Modern anesthesia and peroperative monitoring methods reduce per- and postoperative mortality during transient occlusion of the middle cerebral artery in rats.
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Modern anesthesia and peroperative monitoring methods reduce per- and postoperative mortality during transient occlusion of the middle cerebral artery in rats.

机译：现代麻醉和围手术期监测方法可降低大鼠大脑中动脉短暂闭塞期间的术前和术后死亡率。

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摘要

Mortality and morbidity during and after occlusion of the middle cerebral artery in rats are important confounding factors which may be minimized by improved anesthesia and peroperative monitoring techniques. We describe state of the art techniques for inducing anesthesia, endotracheal intubation, ventilation and monitoring peroperatively in this context. Introducing the subtemporal approach of Tamura et al. in our laboratory 5 years ago, we experienced 25% peroperative and 24 h postoperative rat mortality when performing temporary clipping of the middle cerebral artery. This prompted us to abandon intraperitoneal anesthesia by chloral hydrate and ventilation by tracheotomy in favor of endotracheal intubation and isoflurane anesthesia (1% isoflurane in 30%:70% O(2)/N(2)O). These anesthetic techniques in combination with improved surgical skills have reduced our initial 25% peroperative- and 24 h postoperative mortality to 2.7% (1.8% peroperatively and 0.9% 24 h postoperatively). Furthermore, the following 14 days postoperative mortality rate was 1.8%. A total number of 203 rats have been operated with this method in different studies where a focal reperfusion stroke model combined with extended periods of observations were the cornerstone.
机译：大鼠大脑中动脉闭塞期间和闭塞后的死亡率和发病率是重要的混杂因素，可以通过改善麻醉和围手术期监测技术将其降至最低。我们描述了在这种情况下，用于诱导麻醉，气管插管，通气和监测的最新技术。介绍Tamura等人的颞下方法。在5年前的实验室中，当临时切断大脑中动脉时，我们的大鼠术中和术后24小时死亡率达到25％。这促使我们放弃使用水合氯醛进行腹膜内麻醉，而采用气管切开术进行换气，转而采用气管插管和异氟烷麻醉（1％异氟烷在30％：70％O（2）/ N（2）O中）。这些麻醉技术与提高的手术技能相结合，使我们的术前和术后24小时的初始死亡率降低了25％，降至2.7％（术前为1.8％，术后24小时为0.9％）。此外，术后14天的死亡率为1.8％。在不同的研究中，总共有203只大鼠用这种方法进行手术，其中以局灶性再灌注卒中模型与延长的观察期相结合为基础。

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