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首页> 外文期刊>Inhalation toxicology >Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice. IV. Characterization of acute and chronic effects of ambient air fine particulate matter exposures on heart-rate variability.
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Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice. IV. Characterization of acute and chronic effects of ambient air fine particulate matter exposures on heart-rate variability.

机译：亚慢性暴露于小鼠集中环境颗粒（CAP）的影响。 IV。表征环境空气细颗粒物暴露对心率变异性的急性和慢性影响。

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摘要

Long-term exposure to fine particulate air pollution (PM2.5) has been associated increased risk of death from cardiopulmonary diseases. Cardiac function parameters have also been affected by ambient particulate matter (PM) exposure, including heart-rate variability (HRV), a measure of autonomic function that has been recognized as a well-defined, quantitative indicator of autonomic dysfunction. However, the role of HRV in ambient PM-induced cardiovascular effect is not fully understood. In an accompanying article, we report significant decreasing patterns of heart rate (HR), body temperature, and physical activity for mice lacking apoliproprotein (ApoE-/-) over 5 mo of exposure to concentrated ambient PM (CAPs), with smaller and nonsignificant change for C57 mice. In this article, we report the effects of subchronic CAPs exposure on HRV parameters that are sensitive to cardiac sympathetic and parasympathetic nerve activity. The standard deviation of normal to normal beat intervals (SDNN) and the squareroot of the mean squared differences of successive RR intervals (RMSSD) in the late afternoon and overnight for the ApoE-/- mice showed a gradual increase for the first 6 wk, a decline for about 12 more wk, and a slight turn upward at the end of the study period. For C57 mice, there were no chronic effect changes of SDNN or RMSSD in the late afternoon, an a slight increase after 6 wk for the overnight period. The response patterns of ApoE-/- mice indicated a perturbation of the homeostatic function in the cardiovascular system (initial enhancement and late depression of the HRV parameters). Our results complement the findings in human panel and controlled CAPs exposure studies in demonstrating that increased levels of particle pollution are able to perturb cardiac autonomic function, which may lead to adverse cardiovascular outcomes.
机译：长期暴露于细颗粒空气污染（PM2.5）中会增加心肺疾病致死的风险。心脏功能参数还受到环境颗粒物（PM）暴露的影响，包括心率变异性（HRV），这是一种自主神经功能的测量方法，已被公认是自主神经功能障碍的明确定义的定量指标。然而，HRV在周围PM诱导的心血管效应中的作用尚不完全清楚。在随附的文章中，我们报告了在暴露于浓缩的环境PM（CAP）后5个月内缺乏载脂蛋白（ApoE-/-）的小鼠的心率（HR），体温和体育活动的显着下降模式，且变小且无统计学意义C57小鼠的变化。在本文中，我们报告了亚慢性CAPs暴露对对心脏交感神经和副交感神经活动敏感的HRV参数的影响。对于ApoE-/-小鼠，正常和正常搏动间隔（SDNN）的标准差以及连续的RR间隔的均方差的平方根（RMSSD）在ApoE-/-小鼠的前6周逐渐增加，下降约12周，在研究期结束时略有上升。对于C57小鼠，在下午晚些时候没有SDNN或RMSSD的慢性影响变化，在过夜6周后略有增加。 ApoE-/-小鼠的反应模式表明心血管系统中的稳态功能受到干扰（HRV参数的初始增强和晚期抑制）。我们的结果补充了人类专家组和CAPs受控暴露研究的结果，表明增加的颗粒物污染水平会扰乱心脏自主功能，这可能导致不良的心血管预后。

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