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首页> 外文期刊>Briefings in functional genomics & proteomics >Environmental proteomics: applications of proteome profiling in environmental microbiology and biotechnology
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Environmental proteomics: applications of proteome profiling in environmental microbiology and biotechnology

机译：环境蛋白质组学：蛋白质组分析在环境微生物学和生物技术中的应用

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In this review, we present the use of proteomics to advance knowledge in the field of environmental biotechnology,including studies of bacterial physiology, metabolism and ecology. Bacteria are widely applied in environmentalbiotechnology for their ability to catalyze dehalogenation, methanogenesis, denitrification and sulfate reduction,among others. Their tolerance to radiation and toxic compounds is also of importance. Proteomics has an impor-tant role in helping uncover the pathways behind these cellular processes. Environmental samples are often highlycomplex, which makes proteome studies in this field especially challenging. Some of these challenges are the lack ofgenome sequences for the vast majority of environmental bacteria, difficulties in isolating bacteria and proteins fromcertain environments, and the presence of complex microbial communities. Despite these challenges, proteomicsoffers a unique dynamic view into cellular function. We present examples of environmental proteomics of modelorganisms, and then discuss metaproteomics (microbial community proteomics), which has the potential to provideinsights into the function of a community without isolating organisms. Finally, the environmental proteomicsliterature is summarized as it pertains to the specific application areas of wastewater treatment, metabolic engi-neering, microbial ecology and environmental stress responses.
机译：在本文中，我们介绍了蛋白质组学的应用，以增进环境生物技术领域的知识，包括细菌生理学，新陈代谢和生态学的研究。细菌具有催化脱卤，甲烷化，反硝化和硫酸盐还原的能力，因此在环境生物技术中得到了广泛应用。它们对辐射和有毒化合物的耐受性也很重要。蛋白质组学在帮助揭示这些细胞过程背后的途径方面具有重要作用。环境样品通常非常复杂，这使得在该领域进行蛋白质组学研究尤其具有挑战性。这些挑战中的一些挑战是，绝大多数环境细菌缺少基因组序列，难以从某些环境中分离细菌和蛋白质，以及存在复杂的微生物群落。尽管存在这些挑战，蛋白质组学仍可提供有关细胞功能的独特动态视图。我们提供了模型生物的环境蛋白质组学示例，然后讨论了元蛋白质组学（微生物群落蛋白质组学），它有可能提供对社区功能的了解，而无需分离生物。最后，对环境蛋白质组学进行了概述，因为它涉及废水处理，代谢工程，微生物生态学和环境胁迫响应的特定应用领域。

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