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首页> 外文期刊>Internal medicine journal >Outcomes for women in a flexible sigmoidoscopy-based colorectal cancer screening programme.
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Outcomes for women in a flexible sigmoidoscopy-based colorectal cancer screening programme.

机译：在基于乙状结肠镜的灵活结肠直肠癌筛查计划中为女性提供的结果。

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BACKGROUND: There are concerns that technical and anatomical factors can reduce the potential benefit of flexible sigmoidoscopy (FS) as a colorectal cancer (CRC) screening tool in women compared with men. Our aim was to review the outcomes for female participants in a community-based CRC screening project using FS. METHODS: In 1995, a programme of unsedated FS-based screening of asymptomatic average-risk individuals aged 55-64 years was established at Fremantle Hospital, Western Australia. Insertion depths, pathological findings and site of adenomas and subject-rated pain scores have been prospectively recorded. Later diagnoses of malignancy were determined by linkage of the cohort with the West Australian Cancer Registry. RESULTS: Between 1995 and 2005, 3402 primary screening FS examinations had been carried out (women 41%). Mean age of participants was 59.6 years. Women were more likely to undergo a FS with insertion depth less than 40 cm (17 vs 6%, P < 0.0001). Mean pain score was 2.9 for men and 4.0 for women (P < 0.0001). Women were less likely to have any neoplasia detected, independent of pain score or insertion depth (odds ratio 0.5, 95% confidence interval 0.4-0.6). Increasing insertion depth from 50 to 60 cm in a woman would only have a 0.4% chance of detecting any additional neoplasia. An insignificant trend to higher incidence of later interval CRC was observed in women with normal sigmoidoscopy. CONCLUSION: Women probably undergo FS with more discomfort and lesser insertion depth than men. It is unlikely that moderate increases in insertion depth would have a substantial benefit.
机译：背景：人们担心，与男性相比，技术和解剖学因素可能会降低柔性乙状结肠镜（FS）作为大肠癌（CRC）筛查工具的潜在益处。我们的目标是使用FS审查基于社区的CRC筛查项目中女性参与者的结果。方法：1995年，在西澳大利亚州的弗里曼特尔医院建立了一个基于镇静剂的基于FS的55-64岁无症状平均风险人群筛查计划。前瞻性地记录了插入深度，病理发现和腺瘤部位以及受试者评分的疼痛评分。该队列与西澳大利亚癌症登记处的联系确定了后来的恶性肿瘤诊断。结果：在1995年至2005年之间，进行了3​​402次初筛FS检查（妇女41％）。参与者的平均年龄为59.6岁。女性更容易接受插入深度小于40 cm的FS（17比6％，P <0.0001）。男性的平均疼痛评分为2.9，女性为4.0（P <0.0001）。女性较少被发现有肿瘤形成，而与疼痛评分或插入深度无关（优势比为0.5，95％置信区间为0.4-0.6）。如果将女性的插入深度从50 cm增加到60 cm，则只有0.4％的机会可以检测到任何其他赘生物。在乙状结肠镜检查正常的女性中观察到更高的发生率，在随后的间隔CRC发生率方面没有明显的趋势。结论：与男性相比，女性进行FS时更不舒服，插入深度更小。插入深度的适度增加不太可能会带来实质性的好处。

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