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首页> 外文期刊>International angiology: A journal of the International Union of Angiology >Trace elements and toxic heavy metals play a role in Buerger disease and atherosclerotic peripheral arterial occlusive disease.
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Trace elements and toxic heavy metals play a role in Buerger disease and atherosclerotic peripheral arterial occlusive disease.

机译：微量元素和有毒重金属在Buerger病和动脉粥样硬化性外周动脉闭塞性疾病中起作用。

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AIM: The aim of the present study was to define the roles of trace elements and toxic heavy metals in Buerger disease and atherosclerotic peripheral arterial occlusive disease (PAOD). METHODS: Seventy-five subjects who were identical in demographic charecteristics were selected for the study; 25 with Buerger disease, 25 with PAOD, 25 healthy volunteers. Serum selenium (Se), zinc (Zn), copper (Cu), iron (Fe),whole blood cadmium (Cd) and lead (Pb), erythrocyte glutathione (GSH), erythrocyte glutathione peroxidase (GSH-Px), erythrocyte and plasma malondialdehyde (MDA) levels were measured. RESULTS: Serum Se and Zn levels were significantly low in patients with Buerger disease compared to patients with PAOD and controls (P<0.001 and P<0.001 respectively). Serum levels of Fe and Zn were also significantly low in patients with PAOD compared to controls (p<0.001 and p<0.05 respectively). In contrast, Cu and Pb levels in Buerger disease group were significantly high compared to PAOD and control groups (P<0.001 and P<0.001 respectively). Erythrocyte GSH and GSH-Px levels were significantly lower in patients with Buerger disease compared to patients with PAOD and controls (P<0.001 and P<0.001 respectively), while erythrocyte and plasma MDA levels were significantly higher (P<0.001 and P<0.001 respectively). CONCLUSION: It can be concluded that the levels of trace elments and toxic heavy metals and oxidative stress influence the disease process in Buerger disease more than PAOD.
机译：目的：本研究的目的是确定微量元素和有毒重金属在Buerger病和动脉粥样硬化性外周动脉闭塞性疾病（PAOD）中的作用。方法：选择75名在人口统计学特征上相同的受试者进行研究。 25位患有Buerger病，25位患有PAOD，25位健康志愿者。血清硒（Se），锌（Zn），铜（Cu），铁（Fe），全血镉（Cd）和铅（Pb），红细胞谷胱甘肽（GSH），红细胞谷胱甘肽过氧化物酶（GSH-Px），红细胞和测量血浆丙二醛（MDA）水平。结果：与PAOD和对照组相比，Buerger病患者的血清Se和Zn水平显着降低（分别为P <0.001和P <0.001）。与对照组相比，PAOD患者的血清铁和锌水平也显着较低（分别为p <0.001和p <0.05）。相反，与PAOD组和对照组相比，Buerger病组的Cu和Pb水平显着较高（分别为P <0.001和P <0.001）。与PAOD和对照组患者相比，Buerger病患者的红细胞GSH和GSH-Px水平显着降低（分别为P <0.001和P <0.001），而红细胞和血浆MDA水平显着更高（P <0.001和P <0.001）分别）。结论可以得出结论，痕量元素和有毒重金属的含量以及氧化应激对Buerger病的病程影响远大于PAOD。

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