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首页> 外文期刊>International endodontic journal >Haemostatic effect and tissue reactions of methods and agents used for haemorrhage control in apical surgery.
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Haemostatic effect and tissue reactions of methods and agents used for haemorrhage control in apical surgery.

机译：用于根尖手术中止血的方法和药剂的止血效果和组织反应。

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AIM: To compare the haemostatic effect and tissue reactions of different agents and methods used for haemorrhage control in apical surgery. METHODOLOGY: Six standardized bone defects were prepared in the calvaria of six Burgundy rabbits. Five haemostatic modalities were tested for their haemostatic effect and tissue reactions, and were compared with untreated control defects: Expasyl + Stasis, Expasyl + Stasi + freshening of the bone defect with a bur, Spongostan, Spongostan+ epinephrine, and electro cauterization. The haemostatic effect was analysed visually and compared using Wilcoxon's signed rank test. Two groups of three animals were evaluated histologically for hard and soft tissue reactions related to the different haemostatic measures, after 3 and 12 weeks of healing respectively. RESULTS: Expasyl + Stasis and electro cauterization proved most effective in reducing bleeding (P < 0.05), but were accompanied by unfavourable tissue reactions, as indicated by the presence of necrotic bone, inflammatory cells and the absence of bone repair. These adverse tissue reactions did not recover substantially over time. However, adverse reactions were not observed when the superficial layer of bone had been removed with a rotary instrument. In contrast, Spongostan + epinephrine showed only a moderate haemostatic effect, but elicited also only mild adverse tissue reactions. CONCLUSIONS: Haemostasis in experimental bone defects is most effectively accomplished by using Expasyl + Stasis or electro cauterization. However, the bone defects should be freshened with a rotary instrument before suturing so as not to compromise healing.
机译：目的：比较根尖手术中不同止血剂和止血方法的止血效果和组织反应。方法：在六只勃艮第家兔的颅骨中准备了六个标准化的骨缺损。测试了五种止血方法的止血效果和组织反应，并与未经处理的对照缺陷进行了比较：Expasyl + Stasis，Expasyl + Stasi + bur，Spongostan，Spongostan +肾上腺素和电灼治疗骨缺损。视觉分析止血效果，并使用Wilcoxon的符号秩检验进行比较。分别在愈合3周和12周后，对两组三只动物进行组织学评估，以了解与不同止血措施相关的硬组织和软组织反应。结果：Expasyl + Stasis和电灼被证明在减少出血方面最有效（P <0.05），但同时伴随不良的组织反应，表现为坏死骨，炎性细胞和缺乏骨修复。随着时间的流逝，这些不良组织反应基本上没有恢复。但是，当用旋转器械去除骨骼的表层时，未观察到不良反应。相反，Spongostan +肾上腺素仅显示中度止血作用，但也仅引起轻度不良组织反应。结论：使用Expasyl + Stasis或电灼可最有效地完成实验性骨缺损的止血。但是，在缝合前应使用旋转器械将骨缺损刷新，以免损害愈合。

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