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首页> 外文期刊>International Dairy Journal >Bioavailability of the antihypertensive peptide LHLPLP: transepithelial flux of HLPLP.
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Bioavailability of the antihypertensive peptide LHLPLP: transepithelial flux of HLPLP.

机译：降压肽LHLPLP的生物利用度：HLPLP的上皮通量。

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摘要

The beta-casein peptide f(133-138), with the sequence LHLPLP, was responsible for angiotensin converting enzyme (ACE)-inhibitory (peptidyl-dipeptidase A) and antihypertensive activity of fermented milk produced with different Enterococcus faecalis strains. The aim of this study was to investigate if the ACE-inhibitory peptide LHLPLP is resistant to brush border peptidases and to examine its mechanism for transepithelial transport using Caco-2 cells. LHLPLP was hydrolysed by cellular peptidases to HLPLP prior to transport across the intestinal epithelium. The effect of some inhibitors on the transport of HLPLP indicated that paracellular passive diffusion is likely to be the main mechanism of transport across the cell layer. This was confirmed by measuring the flux of the peptide after reversion of the flux from the basolateral to the apical chamber. In vitro incubation HLPLP in human plasma showed that the peptide remained practically intact 1 h after incubation and degraded by 50% at 2 h of incubation.
机译：具有序列LHLPLP的β-酪蛋白肽f（133-138）负责血管紧张素转化酶（ACE）的抑制（肽基-二肽酶A）和由不同粪肠球菌菌株生产的发酵乳的降压活性。这项研究的目的是调查ACE抑制肽LHLPLP是否对刷状缘肽酶具有抗性，并研究其使用Caco-2细胞跨上皮运输的机制。在通过肠上皮转运之前，LHLPLP被细胞肽酶水解为HLPLP。某些抑制剂对HLPLP转运的影响表明，细胞旁的被动扩散可能是跨细胞层转运的主要机制。这是通过测量通量从基底外侧流向根尖室后的肽通量来证实的。在人血浆中的体外温育HLPLP显示，温育1小时后该肽实际上保持完整，并在温育2 h降解了50％。

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