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首页> 外文期刊>International journal of antimicrobial agents >Antimicrobial resistance among non-fermentative Gram-negative bacilli isolated from the respiratory tracts of Italian inpatients: a 3-year surveillance study by the Italian Epidemiological Survey
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Antimicrobial resistance among non-fermentative Gram-negative bacilli isolated from the respiratory tracts of Italian inpatients: a 3-year surveillance study by the Italian Epidemiological Survey

机译：从意大利住院病人的呼吸道分离出的非发酵革兰阴性杆菌中的抗菌素耐药性：一项由意大利流行病学调查进行的为期3年的监测研究

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The Italian Epidemiological Survey evaluated antibiotic susceptibility of non-fermentative Gram-negative bacilli isolated from inpatient respiratory-tract specimens collected throughout Italy during 1997-1999. The minimal inhibitory concentrations of 14 antibiotics for 1474 Pseudomonas aeruginosa strains, 307 Stenotrophomonas maltophilia strains and 114 Acinetobacter baumannii strains were determined in 57 clinical microbiology laboratories by means of a standardised micro-dilution method. The most active drugs against P. aeruginosa isolates were meropenem (81% susceptible) and amikacin (80% susceptible). Imipenem and meropenem proved to be the only agents active against A. baumannii isolates, although 13 and 16%, respectively, of strains were resistant to these drugs. Trimethoprim-sulphamethoxazole (TMP-SMZ) showed activity only against S. maltophilia isolates (83% susceptible). A total of 185 multidrug-resistant P aeruginosa isolates (resistant to piperacillin, ceftazidime, gentamicin, and imipenem) were found. Resistance rates and trends showed consistent regional variations, including sharp increases from 1997 to 1999 in imipenem resistance among P. aeruginosa isolates from central and southern Italy. (C) 2003 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved. [References: 71]
机译：意大利流行病学调查评估了从1997-1999年整个意大利收集的住院呼吸道标本中分离出的非发酵性革兰氏阴性细菌的药敏性。通过标准化的微稀释法，在57个临床微生物实验室中确定了1474种铜绿假单胞菌菌株，307种嗜麦芽单胞菌和114种鲍曼不动杆菌的14种抗生素的最低抑菌浓度。对抗铜绿假单胞菌分离物最有效的药物是美罗培南（敏感度为81％）和丁胺卡那霉素（敏感度为80％）。亚胺培南和美罗培南被证明是唯一对鲍曼不动杆菌分离物具有活性的药物，尽管分别有13％和16％的菌株对这些药物具有抗性。甲氧苄啶-硫代甲恶唑（TMP-SMZ）仅显示对嗜麦芽孢杆菌分离株的活性（83％易感）。总共发现了185种多药耐药铜绿假单胞菌菌株（对哌拉西林，头孢他啶，庆大霉素和亚胺培南有耐药性）。耐药率和趋势显示出一致的区域差异，包括1997年至1999年意大利中部和南部的铜绿假单胞菌分离株亚胺培南耐药性急剧增加。 （C）2003年Elsevier B.V.和国际化学疗法学会。版权所有。 [参考：71]

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