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The use of psychotropics and survival in demented elderly individuals.

机译:老年痴呆症患者的精神药物使用和生存。

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The present study aimed to examine the use of psychotropics and its relation to survival in demented elderly persons. A random sample of 700 individuals, aged 75 years or older, was drawn from the population of Kuopio city in January 1998. A geriatrician and a nurse carried out clinical examinations of 601 individuals, of whom 137 suffered from dementia according to DSM-IV criteria. The lifespan was calculated from the date of examination in 1998 to the end of 2003. In survival analyses, subjects were divided according to psychotropic use into groups: (i) users of only one of kind of psychotropics and (ii) concomitant users of all kinds of psychotropics. Psychotropics were classified into antipsychotics, antidepressants and a group of anxiolytics and hypnotics/sedatives. Seventy-one percent (n=97) of demented elderly individuals used a psychotropic drug. Age- and sex-adjusted survival did not differ by severity of dementia (P=0.076) or by the diagnosis of dementia (P=0.54). When survival was compared with nonusers of psychotropics, the hazard ratio was 2.75 (P=0.002) for individuals who used antipsychotics as their only psychotropic medicine and 1.76 (95% confidence interval 1.09-2.86) for concomitant users of all kinds of psychotropics. The use of several psychotropics or antipsychotics is a risk factor for death in demented elderly persons.
机译:本研究旨在探讨精神药物的使用及其与老年痴呆症患者生存的关系。 1998年1月,从库奥皮奥市人口中随机抽取700名年龄在75岁以上的人作为样本。一名老年医师和一名护士对601名个体进行了临床检查,其中根据DSM-IV标准,其中137名患有痴呆症。寿命是从1998年检查之日到2003年底计算的。在生存分析中,根据精神药物的使用将受试者分为几类:(i)仅使用一种精神药物的使用者和(ii)所有精神药物的同时使用者各种精神药物。精神药物分为抗精神病药,抗抑郁药和一组抗焦虑药和催眠药/镇静药。痴呆的老年人中有71%(n = 97)使用了精神药物。年龄和性别调整后的生存率在痴呆严重程度(P = 0.076)或痴呆诊断(P = 0.54)方面没有差异。将生存率与未使用精神科药物的使用者进行比较时,使用抗精神病药作为唯一精神科药物的个体的危险比是2.75(P = 0.002),同时使用各种精神科药物的使用者的危险比是1.76(95%置信区间1.09-2.86)。使用多种精神药物或抗精神病药是老年痴呆症患者死亡的危险因素。

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