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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Bush Sophora Root polysaccharide and its sulfate can scavenge free radicals resulted from duck virus hepatitis
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Bush Sophora Root polysaccharide and its sulfate can scavenge free radicals resulted from duck virus hepatitis

机译：布什槐花根多糖及其硫酸盐可清除鸭病毒性肝炎引起的自由基

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摘要

In order to study the antioxidant effect of Bush Sophora Root polysaccharide (BSRPS) and its sulfate on anti-duck virus hepatitis (DVH), sulfated Bush Sophora Root polysaccharide (sBSRPS) was prepared by chlorosulfonic acid-pyridine method. Ducklings were fed with BSRPS and sBSRPS after challenged DHAV. Death was monitored, evaluation indexes of peroxidative and hepatic injury at the initial (4th and 8th hour) and later (54th hour) stages were detected. The results showed afine treatment effect of BSRPS and sBSRPS. Visual hepatic pathological injury severities were less serious after the treatment. At the initial stage, free radical levels in all groups were the same, and BSRPS and sBSRPS reduced the hepatic injury through inhibiting virus replication. At the later stage, mass free radicals were detected in VC group while free radical levels in BSRPS and sBSRPS groups were significantly lower than VC group. The antioxidant effect of BSRPS and sBSRPS might alleviate the hepatic injury. Abbreviations: DHAV, duck hepatitis A virus; MDA, malondialdehyde; DVH, duck virus hepatitis; SOD, superoxide dismutase; GSH-Px, glutathione peroxidase; NO, nitric oxide; ROS, reactive oxygen species; RNS, reactive nitrogen species; NOS, nitric oxide synthase; iNOS, inducible nitric oxide synthase; BSRPS, Bush Sophora Root polysaccharide; sBSRPS, sulfated Bush Sophora Root polysaccharide; CAT, catalase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; LDH, lactate dehydrogenase; TP, total protein; ALB, albumin; GLO,globulin; VC, virus control; BC, blank control.
机译：为研究布什槐豆多糖（BSRPS）及其硫酸盐对鸭鸭肝炎（DVH）的抗氧化作用，采用氯磺酸-吡啶法制备了硫酸布什槐豆多糖（sBSRPS）。攻击DHAV后，给小鸭喂食BSRPS和sBSRPS。监测死亡，在最初（第4和第8小时）和以后（第54小时）评估过氧化和肝损伤的评估指标。结果显示BSRPS和sBSRPS有良好的治疗效果。治疗后视觉肝病理损伤严重程度较轻。在初始阶段，所有组的自由基水平都相同，并且BSRPS和sBSRPS通过抑制病毒复制减少了肝损伤。在后期阶段，VC组中检测到大量自由基，而BSRPS和sBSRPS组中的自由基水平显着低于VC组。 BSRPS和sBSRPS的抗氧化作用可以减轻肝损伤。缩写：DHAV，鸭甲型肝炎病毒; MDA，丙二醛; DVH，鸭病毒性肝炎; SOD，超氧化物歧化酶; GSH-Px，谷胱甘肽过氧化物酶;一氧化氮ROS，活性氧; RNS，活性氮; NOS，一氧化氮合酶; iNOS，诱导型一氧化氮合酶; BSRPS，布什槐树根多糖; sBSRPS，硫酸化的布什槐豆根多糖; CAT，过氧化氢酶; ALT，丙氨酸转氨酶; AST，天冬氨酸转氨酶; ALP，碱性磷酸酶; LDH，乳酸脱氢酶; TP，总蛋白; ALB，白蛋白; GLO，球蛋白; VC，病毒控制; BC，空白对照。

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