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首页> 外文期刊>International clinical psychopharmacology >Clonazepam treatment of lysergic acid diethylamide-induced hallucinogen persisting perception disorder with anxiety features.
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Clonazepam treatment of lysergic acid diethylamide-induced hallucinogen persisting perception disorder with anxiety features.

机译：氯硝西am治疗麦角酸二乙酰胺诱导的致幻剂持续性认知障碍，具有焦虑特征。

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摘要

An unique and intriguing characteristic of lysergic acid diethylamide (LSD) and LSD-like substances is the recurrence of some of the symptoms which appear during the intoxication, in the absence of recent intake of hallucinogens. Hallucinogen persisting perception disorder (HPPD) is a condition in which the re-experiencing of one or more perceptual symptoms causes significant distress or impairment in social, occupational or other important areas of functioning and may be extremely debilitating. Benzodiazepines are one of the recommended agents for the treatment of HPPD but it is unclear which of them may be more helpful. The goal of our investigation was to assess the efficacy of clonazepam in the treatment of LSD-induced HPPD. Sixteen patients fulfilled entrance criteria. All complained of HPPD with anxiety features for at least 3 months and were drug free at least 3 months. They received clonazepam 2 mg/day for 2 months. Follow-up was continued for 6 months. They were weekly evaluated during the 2 months of clonazepam administration and monthly during the follow-up period using the Clinical Global Impression Scale, a Self-report Scale and Hamilton Anxiety Rating Scale. Patients reported a significant relief and the presence of only mild symptomatology during the clonazepam administration. This improvement was clearly sustained and persisted during a 6-month follow-up period. This study suggests that high potency benzodiazepines like clonazepam, which has serotonergic properties, may be more effective than low-potency benzodiazepines in the treatment of some patients with LSD-induced HPPD.
机译：麦角酸二乙酰胺（LSD）和类LSD物质的独特且令人着迷的特征是在醉酒过程中某些症状的复发，而最近没有摄入致幻剂。致幻剂持续性知觉障碍（HPPD）是一种病状，其中一种或多种知觉症状的重新出现会导致社交，职业或其他重要功能领域的严重困扰或损害，并且可能使人极度虚弱。苯二氮卓类药物是治疗HPPD的推荐药物之一，但尚不清楚它们中哪一种可能更有用。我们研究的目的是评估氯硝西am治疗LSD诱发的HPPD的疗效。 16名患者符合入院标准。所有人都抱怨HPPD焦虑症至少持续3个月，并且至少3个月没有药物。他们接受了每天2毫克的氯硝西am 2个月。随访持续了6个月。在使用氯硝西am的2个月内每周进行评估，并在随访期间每月使用临床总体印象量表，自我报告量表和汉密尔顿焦虑量表对他们进行评估。在氯硝西am给药期间，患者报告症状明显缓解，仅出现轻度症状。这种改善明显持续并在6个月的随访期内持续存在。这项研究表明，具有血清素能特性的高效苯二氮卓类药物（如氯硝西am）在某些LSD诱发的HPPD患者中可能比低效苯二氮卓类药物更有效。

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