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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Preparation of semi-interpenetrating polymer networks composed of silk fibroin and poloxamer macromer
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Preparation of semi-interpenetrating polymer networks composed of silk fibroin and poloxamer macromer

机译：丝素蛋白与泊洛沙姆大分子单体组成的半互穿聚合物网络的制备

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摘要

A system was designed to utilize silk fibroin (SF) as a matrix for wound dressing. For this system, we prepared a sponge type of porous semi-interpenetrating networks (SIPNs) hydrogel composed of SF and poloxamer 407 macromer to enhance the mechanical and functional properties of SF. The thermal and mechanical properties of the hydrogels as well as their swelling behaviors were studied by means of differential scanning calorimetry, compressive modulus measurement, and gravimetric method, respectively. The morphology and crystalline structure of these SIPN hydrogels were also investigated by scanning electron microscopy (SEM) and wide-angle diffractometry, respectively. Conformational change of SF from random coil to P-sheet structure was accelerated by formation of SIPNs with poloxamer. The melting temperature of poloxamer in the SIPNs decreased due to the prevention of crystallization by the incorporation of SE The mechanical strength of SIPNs hydrogel was much higher than those of SF itself or SF/poloxamer blend and increased with the poloxamer content. The equilibrium water content of SF was remarkably increased by formation of SIPNs with poloxamer due to the hydrophilicity of poloxamer. The crystallinity and morphology of SIPNs hydrogel were affected by SIPNs hydrogel composition. (C) 2004 Elsevier B.V. All rights reserved.
机译：设计一种系统，以利用丝素蛋白（SF）作为伤口包扎的基质。对于该系统，我们制备了由SF和泊洛沙姆407大分子单体组成的海绵型多孔半互穿网络（SIPNs）水凝胶，以增强SF的机械和功能特性。分别通过差示扫描量热法，压缩模量测定法和重量分析法研究了水凝胶的热，机械性能及其溶胀行为。还分别通过扫描电子显微镜（SEM）和广角衍射法研究了这些SIPN水凝胶的形态和晶体结构。通过泊洛沙姆形成SIPNs，促进了SF从无规卷曲到P-片状结构的构象变化。 SIPNs中泊洛沙姆的熔化温度由于加入SE阻止了结晶作用而降低。SIPNs水凝胶的机械强度远高于SF本身或SF /泊洛沙姆共混物的机械强度，并随泊洛沙姆含量的增加而增加。由于泊洛沙姆的亲水性，通过与泊洛沙姆形成SIPNs，SF的平衡水含量显着增加。 SIPNs水凝胶的结晶度和形态受SIPNs水凝胶组成的影响。 （C）2004 Elsevier B.V.保留所有权利。

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