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首页> 外文期刊>International journal of aromatherapy >The effect of aloe vera gel on the anti-acne properties of the essential oil of Ocimum gratissimum Linn leaf - a preliminary clinical investigation
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The effect of aloe vera gel on the anti-acne properties of the essential oil of Ocimum gratissimum Linn leaf - a preliminary clinical investigation

机译:芦荟凝胶对免费赠送的Ocimum gratissimum Linn叶精油抗痤疮特性的影响-初步临床研究

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Aim:This study was designed to investigate possible synergistic effect of aloe vera gel on the anti-acne properties of Ocimum gratissimum oil and to compare the activities of both agents singly and in combinations with the anti-acne agent Dalacin~(TM)- a 1% Clindamycin phosphate solution.Methods: 84 subjects presenting with clinically significant Acne vulgaris (mainly undergraduates of a University) were randomly assigned into seven groups and treated with different test preparations (2% v/v Ocimum oil lotion containing graded concentrations (0-approx 100%) of aloe gel, placebo or control preparations). Samples tested were applied to the face after washing morning and evening. The numbers of inflammatory lesions (papules and pustules) were counted prior to application and daily for 4 weeks. The efficacy of the preparations was rated in terms of product activity (1/D), which is the reciprocal value of the number of days taken to achieve 50% reduction in lesion count.Results: The efficacy of the Ocimum oil lotion products increased with increasing aloe gel contents. Products formulated with the undiluted or 50% aloe gels were most active and resolved inflammatory lesions faster than the standard product. The aloe gel alone showed minimal activity. Adverse effect was mild and tolerable. Conclusion: Aloe vera gel enhanced the anti-acne properties of Ocimum oil; the oil or its combination with aloe vera gel is more effective than 1% Clindamycin in the treatment of Acne vulgaris.
机译:目的:本研究旨在研究芦荟凝胶对Ocimum gratissimum油的抗痤疮特性的可能的协同作用,并比较这两种药物的活性以及与抗痤疮药物Dalacin〜(TM)-a的组合。 1%磷酸克林霉素溶液。方法:将84名临床上具有寻常性寻常痤疮的受试者(主要是大学的本科生)随机分为7组,并用不同的测试制剂(2%v / v含分级浓度(0-约100%的芦荟凝胶,安慰剂或对照制剂)。早上和晚上洗完后,将测试的样品涂在脸上。在应用之前并每天连续4周计算炎症性病变(丘疹和脓疱)的数量。制剂的功效以产品活性(1 / D)进行评估,这是减少病灶数减少50%所花费的天数的倒数。结果:Ocimum油洗剂产品的功效随着增加芦荟凝胶含量。用未稀释或50%芦荟凝胶配制的产品比标准产品具有更快的活性和更快的炎症损伤。单独的芦荟凝胶显示最小的活性。不良反应轻微,可以忍受。结论:芦荟凝胶增强了罗汉果油的抗粉刺性能。该油或其与芦荟凝胶的组合在治疗寻常痤疮方面比1%克林霉素更有效。

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