Curcumin ((1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), the yellow biphenolic pigment isolated from turmeric (Curcuma longa), has various medicinal benefits through antioxidation, anti-inflammation, cardiovascular protection, immunomodulation, enhancing of the apoptotic process, and antiangiogenic property. We explored the effects of curcumin in vitro (10~(?5) M to 10~(?8) M) and in vivo (340 and 170mg/kg b.w., oral) on Na~+/K~+ ATPase (NKA), Na~+/H~+ exchanger (NHE) activity, and membrane lipid hydroperoxides (ROOH) in control and experimental oxidative stress erythrocytes ofWistar rats. As a result, we found that curcumin potently modulated the membrane transporters activity with protecting membrane lipids against hydroperoxidation in control as well as oxidatively challenged erythrocytes evidenced by stimulation of NKA, downregulation of NHE, and reduction of ROOH in the membrane.The observed results corroborate membrane transporters activity with susceptibility of erythrocyte membrane towards oxidative damage. Results explain the protective mechanism of curcumin against oxidative stress mediated impairment in ions-transporters activity and health beneficial effects.
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机译：姜黄素（（1E，6E）-1,7-双（4-羟基-3-甲氧基苯基）-1,6-庚二烯-3,5-二酮）是一种从姜黄（姜黄）中分离出的黄色双酚类颜料通过抗氧化，抗发炎，心血管保护，免疫调节，增强细胞凋亡过程和抗血管生成特性，具有医学上的益处。我们探索了姜黄素在体外（10〜（？5）M至10〜（？8）M）和体内（340和170mg / kg bw，口服）对Na〜+ / K〜+ ATPase（NKA）的影响Wistar大鼠的对照和实验氧化应激红细胞中的NaCl，Na〜+ / H〜+交换子（NHE）活性和膜脂质氢过氧化物（ROOH）。结果，我们发现姜黄素有效地调节了膜转运蛋白的活性，保护了膜脂质免受对照中的氢过氧化作用以及氧化性红细胞的刺激，表现为NKA的刺激，NHE的下调和膜中ROOH的减少。观察到的结果证实了这一点。膜转运蛋白活性与红细胞膜对氧化损伤的敏感性。结果解释了姜黄素对氧化应激介导的离子转运蛋白活性损害和健康有益作用的保护机制。
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