...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Cell Biology >KSHV-Encoded MicroRNAs: Lessons for Viral Cancer Pathogenesis and Emerging Concepts
【24h】

KSHV-Encoded MicroRNAs: Lessons for Viral Cancer Pathogenesis and Emerging Concepts

机译：KSHV编码的microRNA：病毒性癌症发病机理和新兴概念的教训

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The human genome contains microRNAs (miRNAs), small noncoding RNAs that orchestrate a number of physiologic processes through regulation of gene expression. Burgeoning evidence suggests that dysregulation of miRNAs may promote disease progression and cancer pathogenesis. Virus-encoded miRNAs, exhibiting unique molecular signatures and functions, have been increasingly recognized as contributors to viral cancer pathogenesis. A large segment of the existing knowledge in this area has been generated through characterization of miRNAs encoded by the human gamma-herpesviruses, including the Kaposi's sarcoma-associated herpesvirus (KSHV). Recent studies focusing on KSHV miRNAs have led to a better understanding of viral miRNA expression in human tumors, the identification of novel pathologic check points regulated by viral miRNAs, and new insights for viral miRNA interactions with cellular ("human") miRNAs. Elucidating the functional effects of inhibiting KSHV miRNAs has also provided a foundation for further translational efforts and consideration of clinical applications. This paper summarizes recent literature outlining mechanisms for KSHV miRNA regulation of cellular function and cancer-associated pathogenesis, as well as implications for interactions between KSHV and human miRNAs that may facilitate cancer progression. Finally, insights are offered for the clinical feasibility of targeting miRNAs as a therapeutic approach for viral cancers.
机译：人类基因组包含microRNA（miRNA），即小的非编码RNA，通过调节基因表达来协调许多生理过程。新兴证据表明，miRNA的失调可能促进疾病进展和癌症发病机理。病毒编码的miRNA具有独特的分子特征和功能，已被越来越多地认为是病毒性癌症发病机理的贡献者。通过表征由人类伽马疱疹病毒（包括卡波西氏肉瘤相关疱疹病毒（KSHV））编码的miRNA，已经掌握了这一领域的大部分现有知识。近期针对KSHV miRNA的研究已使人们更好地了解了人类肿瘤中病毒miRNA的表达，鉴定了由病毒miRNA调节的新型病理检查点以及有关病毒miRNA与细胞（“人”）miRNA相互作用的新见解。阐明抑制KSHV miRNA的功能作用也为进一步的翻译努力和临床应用的考虑奠定了基础。本文概述了最近的文献，概述了KSHV miRNA调控细胞功能和癌症相关发病机制的机制，以及对KSHV与人类miRNA之间相互作用的暗示，这些相互作用可能促进癌症的进展。最后，提供了针对miRNA作为病毒性癌症治疗方法的临床可行性的见解。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号