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首页> 外文期刊>International Journal of Cell Biology >The Plasma Membrane Potential and the Organization of the Actin Cytoskeleton of Epithelial Cells
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The Plasma Membrane Potential and the Organization of the Actin Cytoskeleton of Epithelial Cells

机译：血浆膜电位和上皮细胞肌动蛋白细胞骨架的组织

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摘要

The establishment and maintenance of the polarized epithelial phenotype require a characteristic organization of the cytoskeletal components. There are many cellular effectors involved in the regulation of the cytoskeleton of epithelial cells. Recently, modifications in the plasma membrane potential (PMP) have been suggested to participate in the modulation of the cytoskeletal organization of epithelia. Here, we review evidence showing that changes in the PMP of diverse epithelial cells promote characteristic modifications in the cytoskeletal organization, with a focus on the actin cytoskeleton. The molecular paths mediating these effects may include voltage-sensitive integral membrane proteins and/or peripheral proteins sensitive to surface potentials. The voltage dependence of the cytoskeletal organization seems to have implications in several physiological processes, including epithelial wound healing and apoptosis.
机译：极化上皮表型的建立和维持需要细胞骨架成分的特征组织。有许多细胞效应子参与上皮细胞的细胞骨架的调节。最近，已经提出质膜电位（PMP）的修饰参与上皮细胞骨架组织的调节。在这里，我们审查的证据表明，多样化的上皮细胞的PMP的变化促进了细胞骨架组织中的特征性修饰，重点是肌​​动蛋白的细胞骨架。介导这些作用的分子途径可以包括电压敏感的整体膜蛋白和/或对表面电位敏感的外周蛋白。细胞骨架组织的电压依赖性似乎在几个生理过程中具有影响，包括上皮伤口愈合和细胞凋亡。

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