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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Characterization and immunomodulatory activities of sulfated polysaccharides from Capsosiphon fulvescens
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Characterization and immunomodulatory activities of sulfated polysaccharides from Capsosiphon fulvescens

机译：辣椒辣椒多糖的表征和免疫调节活性。

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摘要

Sulfated polysaccharides isolated from Capsosiphon fulvescens and fractionated using ion-exchange chromatography were investigated to determine their chemical and molecular characteristics and biological activities. The crude and fractionated polysaccharides (F _1, F _2, and F _3) consisted mostly of carbohydrates (28.9-67.0%), uronic acids (1.6-9.2%) and sulfates (5.2-13.4%) with various amounts of proteins (2.1-53.7%). Their monosaccharide levels were significantly different including rhamnose (20.8-65.2%), xylose (13.0-37.1%) and mannose (11.6-65.1%). The polysaccharides contained one or two subfractions with molecular weights (M _w) ranging from 401.7×10 ~3 to 6232×10 ~3g/mol. These polysaccharides (the crude and fraction F _2) strongly stimulated macrophage cells, RAW264.7 cell line, producing considerable amounts of NO, PGE _2 and cytokines which suggested that they could be strong immunostimulators. The main backbone of the most immunoenhancing polysaccharide (F _2) was suggested by GC-MS and NMR to be the following:.
机译：研究了从辣椒粉辣椒中分离出的硫酸化多糖，并使用离子交换色谱法进行了分级分离，以确定其化学和分子特性以及生物学活性。粗制和分馏多糖（F _1，F _2和F _3）主要由碳水化合物（28.9-67.0％），糖醛酸（1.6-9.2％）和硫酸盐（5.2-13.4％）以及各种蛋白质（2.1）组成。 -53.7％）。它们的单糖水平显着不同，包括鼠李糖（20.8-65.2％），木糖（13.0-37.1％）和甘露糖（11.6-65.1％）。所述多糖包含一个或两个分子量为401.7×10〜3至6232×10〜3g / mol的亚级分。这些多糖（粗多糖和F _2级分）强烈刺激巨噬细胞RAW264.7细胞系，产生大量的NO，PGE _2和细胞因子，提示它们可能是强大的免疫刺激剂。 GC-MS和NMR表明，具有最大免疫增强能力的多糖（F _2）的主要骨架如下：

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