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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Chaperone-like activity of heme group against amyloid-like fibril formation by hen egg ovalbumin: Possible mechanism of action
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Chaperone-like activity of heme group against amyloid-like fibril formation by hen egg ovalbumin: Possible mechanism of action

机译：血红素基团的伴侣样活性对鸡蛋卵白蛋白形成淀粉样样原纤维的作用：可能的作用机理

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摘要

It is well accepted that porphyrins related to heme, are effectively able to act as pharmaceutical. For instance, they were found to interfere with the aggregation of __-amyloid peptide. In present study, the influence of heme concentration on the amyloid-type aggregation of ovalbumin was investigated. We provided experimental evidence of heme's prevention of ovalbumin aggregation in the heat-denaturation process using spectroscopic measurements. Different types of interactions were suggested to be involved in heme-ovalbumin amyloid communication. Since the consequence of heme-attenuated fibrillogenesis is yet to be identified, additional data on chaperoning role of heme may help us to manage amyloid aggregation processes.
机译：众所周知，与血红素有关的卟啉能够有效地用作药物。例如，发现它们干扰α-淀粉样肽的聚集。在本研究中，研究了血红素浓度对卵清蛋白淀粉样类型聚集的影响。我们提供了分光光度法测定血红素在热变性过程中预防卵白蛋白聚集的实验证据。建议在血红素-卵清蛋白淀粉样蛋白的沟通中涉及不同类型的相互作用。由于血红素减弱的原纤维形成的后果尚待确定，因此有关血红素伴侣作用的其他数据可能有助于我们管理淀粉样蛋白聚集过程。

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