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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >The preparation and antioxidant activity of 2-[phenylhydrazine (or hydrazine)-thiosemicarbazone]-chitosan
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The preparation and antioxidant activity of 2-[phenylhydrazine (or hydrazine)-thiosemicarbazone]-chitosan

机译：2- [苯肼（或肼）-硫代半脲]-壳聚糖的制备及抗氧化活性

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摘要

Chitosan (CS) with two different molecular weight were modified by reacting with methyl hydrazine-dithiocarboxylate and methyl phenylhydrazine-dithiocarboxylate to give 2-(hydrazine-thiosemicarbazone)-chitosan (2-HTCHCS, 2-HTCLCS) and 2-(phenylhydrazine-thiosemicarbazone)-chitosan (2-PHTCHCS, 2-PHTCLCS). The structure of the derivatives was characterized by FT-IR spectroscopy and elemental analysis. The antioxidant activities of the derivatives were investigated employing various established systems, such as hydroxyl radical (OH)/superoxide anion (O_2~(.-)) scavenging/reducing power and chelating activity. All of the derivatives showed strong scavenging activity on hydroxyl radical than chitosan and ascorbic acid (Vc), and IC_(50) of 2-HTCHCS, 2-HTCLCS, 2-PHTCHCS and 2-PHTCLCS was 0.362, 0.263, 0.531 and 0.336mg/mL respectively. The inhibitory activities of the derivatives toward superoxide radical by the PMS-NADH system were strong. The results showed that the superoxide radical scavenging effect of 2-[phenylhydrazine (or hydrazine)-thiosemicarbazone]-chitosan were higher than that of chitosan. The derivatives had obviously reducing power and chelating activity. The data obtained from vitro models clearly establish the antioxidant potency of 2-[phenylhydrazine (or hydrazine)-thiosemicarbazone]-chitosan.
机译：通过与肼-二硫代羧酸甲酯和苯基肼-二硫代羧酸甲酯反应，改性了两种不同分子量的壳聚糖（CS），得到了2-（肼基-硫代半氨基甲酸酯）-壳聚糖（2-HTCHCS，2-HTCLCS）和2-（苯基肼基-硫代半氨基甲酸酯） -壳聚糖（2-PHTCHCS，2-PHTCLCS）。通过FT-IR光谱和元素分析表征衍生物的结构。使用各种已建立的体系，如羟基自由基（OH）/超氧阴离子（O_2〜（.-））清除/还原能力和螯合活性，研究了衍生物的抗氧化活性。所有的衍生物都比壳聚糖和抗坏血酸（Vc）具有更强的清除羟基自由基的能力，2-HTCHCS，2-HTCLCS，2-PHTCHCS和2-PHTCLCS的IC_（50）为0.362、0.263、0.531和0.336mg / mL。 PMS-NADH体系对衍生物的超氧自由基的抑制作用很强。结果表明，2- [苯肼（或肼）-硫代半脲酮]-壳聚糖的超氧自由基清除作用高于壳聚糖。衍生物具有明显的降低能力和螯合活性。从体外模型获得的数据清楚地确定了2- [苯肼（或肼）-硫代半脲]-壳聚糖的抗氧化能力。

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