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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Fabrication of chitin-chitosanano TiO2-composite scaffolds for tissue engineering applications
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Fabrication of chitin-chitosanano TiO2-composite scaffolds for tissue engineering applications

机译：用于组织工程应用的几丁质-壳聚糖/纳米TiO2复合支架的制备

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摘要

In this study, we prepared chitin-chitosanano TiO_2 composite scaffolds using lyophilization technique for bone tissue engineering. The prepared composite scaffold was characterized using SEM, XRD, FTIR and TGA. In addition, swelling, degradation and biomineralization capability of the composite scaffolds were evaluated. The developed composite scaffold showed controlled swelling and degradation when compared to the control scaffold. Cytocompatibility of the scaffold was assessed by MTT assay and cell attachment studies using osteoblast-like cells (MG-63), fibroblast cells (L929) and human mesenchymal stem cells (hMSCs). Results indicated no sign of toxicity and cells were found attached to the pore walls within the scaffolds. These results suggested that the developed composite scaffold possess the prerequisites for tissue engineering scaffolds and it can be used for tissue engineering applications.
机译：在这项研究中，我们使用冻干技术制备了几丁质-壳聚糖/纳米TiO_2复合支架，用于骨组织工程。使用SEM，XRD，FTIR和TGA对制备的复合支架进行表征。另外，评估了复合支架的溶胀，降解和生物矿化能力。与对照支架相比，开发的复合支架表现出受控的溶胀和降解。通过MTT测定和使用成骨细胞样细胞（MG-63），成纤维细胞（L929）和人间充质干细胞（hMSC）的细胞附着研究评估支架的细胞相容性。结果表明没有毒性迹象，并且发现细胞附着在支架内的孔壁上。这些结果表明，开发的复合支架具有组织工程支架的先决条件，并且可以用于组织工程应用。

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