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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Liposome and epimedium polysaccharide-propolis flavone can synergistically enhance immune effect of vaccine
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Liposome and epimedium polysaccharide-propolis flavone can synergistically enhance immune effect of vaccine

机译：脂质体和淫羊ium多糖蜂胶黄酮可以协同增强疫苗的免疫效果

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摘要

Three preparations of epimedium polysaccharide-propolis flavone immunopotentiator (EPI), EPI liposome, EPI suspension and EPI watery solution were prepared. In immune response test, their adjuvanticities were compared in 14-day-old chickens vaccinated with Newcastle disease (ND) vaccine. In immune protection test, the effects of the three preparations on Newcastle disease virus (NDV) infection were compared in chickens vaccinated with ND vaccine then challenged with NDV. The results displayed that EPI liposome could enhance the antibody titer, T lymphocyte proliferation and the concentrations of interferon-γ and interleukin-6, when compared with the other two preparations. In EPI liposome group, the antibody titers, lymphocyte proliferation and protective rate were the highest, while the mortality and morbidity were the lowest, in comparison with the other groups. These results indicated that liposome could enhance the immune effect of EPI on ND vaccine and would be expected as the suitable dosage form of this immunopotentiator.
机译：制备了淫羊med多糖蜂胶黄酮免疫增强剂（EPI），EPI脂质体，EPI悬浮液和EPI水溶液三种制剂。在免疫反应测试中，在接种了新城疫（ND）疫苗的14天大的鸡中比较了它们的佐剂性。在免疫保护测试中，比较了三种疫苗对新城疫病毒（NDV）感染的影响，这些疫苗分别接种了ND疫苗和NDV攻击的鸡。结果表明，与其他两种制剂相比，EPI脂质体可提高抗体效价，T淋巴细胞增殖以及干扰素-γ和白介素-6的浓度。与其他组相比，EPI脂质体组的抗体滴度，淋巴细胞增殖和保护率最高，而死亡率和发病率最低。这些结果表明脂质体可以增强EPI对ND疫苗的免疫作用，并有望作为该免疫增强剂的合适剂型。

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