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首页> 外文期刊>International journal of biomedical nanoscience and nanotechnology >Bio-based calcium carbonate (CaCO_3) nanoparticles for drug delivery applications
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Bio-based calcium carbonate (CaCO_3) nanoparticles for drug delivery applications

机译：用于药物输送应用的生物基碳酸钙（CaCO_3）纳米颗粒

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摘要

Targeted delivery of a cytotoxic drug using a drug delivery system could maximise the efficacy of the drug and reduce the side effects. Calcium carbonate (CaCO_3) nanoparticles are highly porous, biocompatible, biodegradable, and have pH-sensitive properties, which makes them good candidates for biological drug delivery systems. In this study, the nanoparticles were derived from egg shells and studied for their drug loading capacity and cytotoxicity, using human colon adenocarcinoma (SW480), and human dermal fibroblast (HDF) cells. The lactate dehydrogenase (LDH) assay indicated a 50% cytotoxicity for SW480 cells at a concentration of 0.3 mg/ml, but there was no cytotoxic effect observed in HDF cells at the same concentration. The anticancer drug 5-fluorouracil (5-FU) and natural compound indole-3-carbinol (13 C) were loaded into CaCO_3 nanoparticles and release profiles were studied. These results showed that the drugs can be loaded in CaCO_3 nanoparticles and released efficiently. The drug loaded nanoparticles were more cytotoxic compared to the as-received drugs alone. The 5FU-loaded nanoparticles in pH 1.0, 5.0, and 7.4 yielded a total loading and release of 86.98 ug, 77.83 ug, and 162.60 ug respectively. Depending on the pH of the solution, up to 162.60 mug of 5-FU was loaded and released from 50 milligrams of the particles, whereas, up to 563.47 micrograms of I3C was loaded and released from similarly loaded particles. These preliminary results indicate the potential of bio-based CaCO_3 nanoparticles in therapeutic applications.
机译：使用药物递送系统靶向递送细胞毒性药物可以最大化药物的功效并减少副作用。碳酸钙（CaCO_3）纳米颗粒具有高度的多孔性，生物相容性，可生物降解性，并且具有pH敏感特性，使其成为生物药物递送系统的理想候选者。在这项研究中，使用人结肠腺癌（SW480）和人皮肤成纤维细胞（HDF）细胞，纳米颗粒衍生自蛋壳，并研究了它们的载药量和细胞毒性。乳酸脱氢酶（LDH）分析显示浓度为0.3 mg / ml的SW480细胞具有50％的细胞毒性，但在相同浓度的HDF细胞中未观察到细胞毒性作用。将抗癌药5-氟尿嘧啶（5-FU）和天然化合物吲哚-3-甲醇（13 C）装入CaCO_3纳米颗粒中，并研究了释放曲线。这些结果表明，该药物可以负载在CaCO_3纳米颗粒中并有效释放。与仅接受药物相比，载有药物的纳米颗粒具有更高的细胞毒性。 pH 1.0、5.0和7.4的5FU负载纳米粒子分别产生的总负载和释放分别为86.98 ug，77.83 ug和162.60 ug。根据溶液的pH值，从50毫克颗粒中最多可装载和释放162.60杯5-FU，而从类似装载的颗粒中最多可装载和释放563.47微克I3C。这些初步结果表明生物基CaCO_3纳米颗粒在治疗应用中的潜力。

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