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首页> 外文期刊>International journal of biomedical nanoscience and nanotechnology >In vitro blood brain barrier models as a screening tool for colloidal drug delivery systems and other nanosvstems
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In vitro blood brain barrier models as a screening tool for colloidal drug delivery systems and other nanosvstems

机译：体外血脑屏障模型作为胶体药物递送系统和其他纳米系统的筛选工具

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摘要

The brain is one of the least accessible organs of the body due to the presence of the blood-brain barrier (BBB), thus making drug delivery to the brain quite a challenge. Various strategies have been explored to circumvent this physiological barrier, including the use of colloidal carriers. These carriers hold great promise as they may increase the delivery of drugs into the brain by protecting them from degradation and prolonging their circulation in the blood, as well as promoting their transport through the BBB. Moreover, functionalisation of these carriers with various ligands allows specific targeting of the central nervous system compartment. Additionally, various in vitro BBB models have been developed and are increasingly useful for screening of drug delivery systems, especially cell-based models that provide mechanistic information. In fact, this paper specifically reviews selected in vitro BBB models as a screening tool for drug delivery colloidal systems.
机译：由于血脑屏障（BBB）的存在，大脑是人体最难以接近的器官之一，因此，将药物输送到大脑是一个很大的挑战。已经探索出各种策略来规避这种生理障碍，包括使用胶体载体。这些载体具有广阔的前景，因为它们可以通过保护药物免于降解并延长其在血液中的循环以及促进其通过血脑屏障的运输来增加药物向大脑的传递。而且，这些带有各种配体的载体的功能化允许对中枢神经系统区室的特异性靶向。另外，已经开发了各种体外BBB模型，并且这些模型对于筛选药物递送系统越来越有用，特别是提供机械信息的基于细胞的模型。实际上，本文专门回顾了选定的体外BBB模型作为药物传递胶体系统的筛选工具。

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