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首页> 外文期刊>International journal of biomedical nanoscience and nanotechnology >Achievements and challenges in the delivery of bioactive molecules by nano-carbon-based systems
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Achievements and challenges in the delivery of bioactive molecules by nano-carbon-based systems

机译：纳米碳基系统输送生物活性分子的成就和挑战

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摘要

The strategic combination of bioactive molecules and drug delivery systems has the advantage of increasing the bioavailability of drugs while improving their safety profiles. Amidst the systems aimed to advance the pharmacological profile of otherwise unfavourable molecules, carbon-based nanomaterials (including nanoparticles, graphite, fullerenes, nanotubes and diamonds) have gained high popularity on the basis of:1 reduced dimensions, which allow them to penetrate into narrow cellular compartments and accumulate in those areas where their presence is most required 2 wide surface area, which could be functionalised with several groups or chains and simultaneously incorporate drugs, targeting molecules or fluorescent probes 3 high resistance, due to their compact structure or the stiffness of the material.Despite these promising factors, this review highlights also some concerns on such carbon-nanosystems and which are mainly attributable to the inability of an exhaustive characterisation and to the potential risks associated with this still-unknown material.
机译：生物活性分子和药物输送系统的战略组合具有增加药物生物利用度，同时改善其安全性的优点。在旨在提高其他不利分子的药理学特征的系统中，基于碳的纳米材料（包括纳米颗粒，石墨，富勒烯，纳米管和钻石）由于以下原因而受到高度欢迎：1尺寸减小，使它们能够渗透到狭窄的空间细胞隔室并聚集在最需要它们存在的区域2宽表面积，可以用数个基团或链进行功能化，并同时掺入药物，靶向分子或荧光探针3具有高抵抗力，因为它们的结构紧凑或刚性强尽管有这些令人鼓舞的因素，本综述也突出了对这种碳纳米系统的一些担忧，这主要归因于无法进行详尽的表征以及与这种仍未知的材料相关的潜在风险。

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