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首页> 外文期刊>International journal of biomedical nanoscience and nanotechnology >Development of nanostructured lipid carriers (NLC) for controlled delivery of meloxicam
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Development of nanostructured lipid carriers (NLC) for controlled delivery of meloxicam

机译：开发用于控制美洛昔康递送的纳米结构脂质载体（NLC）

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Nanostructured lipid carriers (NLC) are becoming increasingly popular due to their obvious advantages over other existing lipid based carriers. They have improved drug encapsulation efficiency and have an ability to reduce drug leakage during storage. The main objective of this study is to develop aqueous dispersions of NLC for the delivery of meloxicam (ME). ME-NLC dispersions were prepared by microemulsion template strategy and characterised for size, polydispersity, zeta potential, drug entrapment efficiency, occlusivity index, and release kinetics. Solid lipid nanoparticles (SLN) and,nanoemulsion (NE) were prepared for comparison. The NLC and SLN showed faster onset of action followed by sustained release due to biphasic release pattern in comparison to the constant release from NE. Compared to NE and SLN, the excellent physical stability of NLC dispersions against drug leakage was seen. NLC showed significant occlusion effect that makes them suitable for topical use.
机译：纳米结构脂质载体（NLC）由于其比其他现有的基于脂质的载体明显的优势而变得越来越受欢迎。它们具有改进的药物封装效率，并具有减少储存过程中药物泄漏的能力。这项研究的主要目的是开发用于递送美洛昔康（ME）的NLC水性分散液。 ME-NLC分散体是通过微乳液模板策略制备的，并且具有尺寸，多分散性，ζ电位，药物截留效率，咬合指数和释放动力学的特征。制备固体脂质纳米颗粒（SLN）和纳米乳液（NE）进行比较。与从NE持续释放相比，NLC和SLN表现出更快的起效，随后由于双相释放模式而持续释放。与NE和SLN相比，NLC分散液具有出色的物理稳定性，可防止药物泄漏。 NLC表现出显着的闭塞作用，使其适合局部使用。

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