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A promising tool for biomolecular nanotechnoiogy blonanoparticles

机译:用于生物分子纳米技术的纳米粒子的有前途的工具

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Bionanoparticles are naturally produced entities that are of nanometre dimension. Viruses like cowpea mosaic virus (CPMV), cowpea chlorotic mottle virus (CCMV), turnip yellow mosaic virus (TYMV), tobacco mosaic virus (TMV), adenovirus, ferritin, and enzyme complexes exemplify these systems, with their precise arrangements of tens to hundreds of molecules into highly organised scaffolds for nucleic acid packaging, metal storage, catalysis or sequestering reactions at the nanometre scale. The purification method involves an efficient tangential flow filtration (TFF), diafiltration and various chromatographic techniques. The bionanoparticles are characterised by using the transmission electron microscopy, scanning electron microscopy and various spectrophotometric methods. One promising medical application of nanotechnoiogy is the targeted delivery of Pharmaceuticals to specific cells within an organism under minimisation of adverse effects for the remaining cells by nanoscale carriers. The branch of bionanotechnology in which naturally occurring nanoparticles are modified and manipulated for various applications is a rich and newly emerging field of research.
机译:生物纳米粒子是自然产生的纳米级实体。像cow豆花叶病毒(CPMV),cow豆绿叶斑驳病毒(CCMV),芜菁黄花叶病毒(TYMV),烟草花叶病毒(TMV),腺病毒,铁蛋白和酶复合物之类的病毒都是这些系统的例证,其精确排列为几十到十亿。数百个分子变成高度组织化的支架,用于纳米级的核酸包装,金属存储,催化或螯合反应。纯化方法涉及有效的切向流过滤(TFF),渗滤和各种色谱技术。通过使用透射电子显微镜,扫描电子显微镜和各种分光光度法来表征生物纳米粒子。纳米技术的一项有前途的医学应用是在将纳米级载体对其余细胞的不利影响降至最低的情况下,将药物靶向递送至生物体内的特定细胞。生物纳米技术的一个分支,其中对天然存在的纳米粒子进行了修饰和操纵以用于各种应用,这是一个新兴的新兴研究领域。

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