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Preparation of water soluble carbon nanotubes and assessment of their biological activity in embryonic zebrafish

机译:水溶性碳纳米管的制备及其在斑马鱼胚胎中的生物学活性评估

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Carbon nanotubes (CNTs) are currently one of the most important classes of nanomaterials with unique properties sparking off numerous applications in many fields, including electronics, material science and medicine. However, applications of CNTs in medicine and other biological fields are hampered by their insolubility in aqueous media and concerns regarding toxicity. In this study, seven types of CNTs, including two single-walled, one double-walled, and four multi-walled, were evaluated for possible toxicological effects. Soluble CNTs were prepared by treatment with a mixture of acids (D_2SO_4 and DNO_3), washed with Milli-Q water and oven dried. Transmission electron microscopy, thermal gravimetric analysis, and other techniques were used to characterise the prepared CNTs. CNT toxicity was assessed using the embryonic zebrafish. Results showed that none of the CNTs studied caused significant adverse developmental effects. These results support the potential safe use of CNTs as components of indwelling medical devices and drug delivery tools.
机译:碳纳米管(CNTs)目前是最重要的一类具有独特性能的纳米材料,在电子,材料科学和医学等许多领域引发了众多应用。但是,由于碳纳米管在水介质中的不溶性以及对毒性的担忧,阻碍了碳纳米管在医学和其他生物领域中的应用。在这项研究中,评估了七种类型的CNT的可能的毒理作用,其中包括两种单壁,一种双壁和四种多壁。通过用酸的混合物(D_2SO_4和DNO_3)处理来制备可溶性CNT,并用Milli-Q水洗涤并用烤箱干燥。使用透射电子显微镜,热重分析和其他技术来表征制备的CNT。使用胚胎斑马鱼评估CNT的毒性。结果表明,所研究的碳纳米管均未引起明显的不良发育影响。这些结果支持了将碳纳米管作为留置医疗设备和药物输送工具的潜在安全用途。

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