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首页> 外文期刊>Biomedical Research >Protective effects of the herbal medicine goshajinkigan in a rat model of non-alcoholic fatty liver disease
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Protective effects of the herbal medicine goshajinkigan in a rat model of non-alcoholic fatty liver disease

机译：草药goshajinkigan对非酒精性脂肪肝大鼠模型的保护作用

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This study was designed to investigate the effect of an herbal medicine-goshajinkigan (GJ)-on the regulation of total body weight, as well as liver and adipose tissue weights in rats fed a highfat diet (HFD) and drinking of 30% sucrose (HFDS) (HFD; the rats received 19.6% energy from carbohydrates, 18.2% from proteins, and 62.2% from lipids; total energy, 506 kcal/100 g). Control rats were fed a standard diet (the rats received 60.5% energy from carbohydrates, 26.2% from proteins, and 13.3% from lipids; total energy, 360 kcal/100 g). Over a period of 12 weeks, rats were allowed free access to either the standard diet or HFDS containing 0, 1, or 3% GJ. In comparison with the control group, the HFDS rats showed a significant decrease in overall body weight and adipose tissue weight, and an increase in liver weight at 12 weeks. GJ treatment significantly reversed the HFDS-induced decrease in body and adipose tissue weight and reduced the elevated liver weight dose-dependently. Similarly, GJ reduced the elevated serum aspartate aminotransferase levels observed in HFDS rats. These results suggest that GJ may have the potential to alleviate damage to the liver in subjects with long-term consumption of HFDS.
机译：这项研究旨在研究高脂饮食（HFD）和饮用30％蔗糖对大鼠的总体重以及肝脏和脂肪组织重量的调节作用。 HFDS）（HFD;大鼠从碳水化合物中获取19.6％的能量，从蛋白质中获取18.2％的能量，从脂质中获取62.2％的能量;总能量为506 kcal / 100 g）。对照组大鼠接受标准饮食（大鼠从碳水化合物中获取60.5％的能量，从蛋白质中获取26.2％的能量，从脂质中获取13.3％的能量;总能量为360 kcal / 100 g）。在12周的时间内，允许大鼠自由摄入标准饮食或含有0％，1％或3％GJ的HFDS。与对照组相比，HFDS大鼠在12周时总体体重和脂肪组织重量显着下降，肝脏重量增加。 GJ治疗显着逆转了HFDS引起的机体和脂肪组织重量减少，并剂量依赖性地降低了肝脏重量增加。同样，GJ降低了在HFDS大鼠中观察到的血清天冬氨酸转氨酶水平升高。这些结果表明，长期服用HFDS的受试者中，GJ可能具有减轻肝脏损害的潜力。

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