• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International journal of clinical pharmacology and therapeutics >The effects of angiotensin II on pulse wave velocity in healthy humans.
【24h】

The effects of angiotensin II on pulse wave velocity in healthy humans.

机译：血管紧张素II对健康人的脉搏波速度的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVES: To examine the dose response relationship between Ang II and pulse wave velocity (an index of arterial stiffness) in healthy human volunteers. DESIGN AND METHODS: We studied 9 healthy male volunteers (mean age 24.7 +/- 0.66 years) in a double-blind, randomized, cross-over, placebo-controlled design. We measured carotid-femoral PWV using a novel device complior. Subjects received placebo, 0.5, 1 and 5 ng/kg/min Ang II as infusions over 30 minutes under standardized conditions. Heart rate, blood pressure and PWV were recorded at baseline and then every 10 minutes during the infusion and twice after the end of the infusion. RESULTS: Systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) in mmHg increased significantly with the 5 ng/kg/min dose compared to placebo (p = 0.004, p -0.007, p = 0.003, respectively). There was no significant difference in SBP, DBP and MAP between 1 and 0.5 ng/kg/min compared to placebo. There was a significant increase in PWV with 5 ng/kg/min dose only compared to placebo (p = 0.02). However, less than 30% of the total Ang II-induced rise in PWV was explained by the Ang II-induced rise in blood pressure (R2 = 0.257). CONCLUSIONS: Ang II increases PWV in healthy human only when given in doses that significantly increase blood pressure. Not all the increase in Ang II-induced rise in PWV can be explained due to Ang II-induced rise in BP.
机译：目的：研究健康人类志愿者中Ang II与脉搏波速度（动脉僵硬度指数）之间的剂量反应关系。设计与方法：我们以双盲，随机，交叉，安慰剂对照设计研究了9名健康男性志愿者（平均年龄24.7 +/- 0.66岁）。我们使用一种新型装置对颈股PWV进行了测量。在标准条件下，受试者在30分钟内接受了0.5、1和5 ng / kg / min Ang II安慰剂的输注。在基线时记录心率，血压和PWV，然后在输注期间每10分钟记录一次，输注结束后记录两次。结果：与安慰剂相比，剂量为5 ng / kg / min时，收缩压（SBP），舒张压（DBP）和平均动脉压（MAP）的mmHg显着增加（p = 0.004，p -0.007，p = 0.003 ， 分别）。与安慰剂相比，SBP，DBP和MAP在1至0.5 ng / kg / min之间无显着差异。仅5 ng / kg / min剂量的PWV与安慰剂相比有显着增加（p = 0.02）。然而，由Ang II引起的血压升高解释了总Ang II引起的PWV升高的不到30％（R2 = 0.257）。结论：只有在显着增加血压的剂量下，Ang II才能增加健康人的PWV。并非所有由Ang II引起的PWV升高的解释都可以归因于Ang II引起的BP升高。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号