...
首页> 外文期刊>International journal of clinical pharmacology and therapeutics >Blocking of integrin-mediated human MV3 melanoma cell binding by commercial and modified heparins.
【24h】

Blocking of integrin-mediated human MV3 melanoma cell binding by commercial and modified heparins.

机译:通过商业和修饰的肝素阻断整联蛋白介导的人MV3黑色素瘤细胞结合。

获取原文
获取原文并翻译 | 示例
           

摘要

Tumor cell metastasis is the most serious complication in the course of malignant diseases. The molecular mechanisms of metastatic tumor spread are complex and not completely understood which complicates pharmacological antimetastatic approaches. Heparin, the anticoagulant drug of choice for more than 70 years, possesses antimetastatic effects, and low-molecular-weight heparins (LMWH) were able to prolong survival in cancer patients in a number of controlled clinical trials [4]. LMWH has no effect on the primary tumor but only on the spread of metastases.
机译:肿瘤细胞转移是恶性疾病过程中最严重的并发症。转移性肿瘤扩散的分子机制是复杂的,尚未完全了解,这使药理抗转移方法变得复杂。肝素是70多年来一直选择的抗凝药物,具有抗转移作用,在许多对照临床试验中,低分子量肝素(LMWH)可以延长癌症患者的生存期[4]。 LMWH对原发肿瘤无影响,仅对转移灶的扩散有影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号