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首页> 外文期刊>International journal of clinical practice >A comparison of the effects of two modified release preparations of nifedipine-nifedipine retard 10 mg twice daily and nifedipine GITS 20 mg once daily--in the treatment of mild to moderate hypertension.
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A comparison of the effects of two modified release preparations of nifedipine-nifedipine retard 10 mg twice daily and nifedipine GITS 20 mg once daily--in the treatment of mild to moderate hypertension.

机译：两种缓释硝苯地平-硝苯地平缓释片（每日两次）和硝苯地平GITS（每日20次）在轻度至中度高血压中的两种疗效比较。

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摘要

A multicentre, randomised, double-blind, cross-over comparison of nifedipine GITS 20 mg once daily and nifedipine retard 10 mg twice daily in 49 patients with mild to moderate hypertension was conducted. Both treatments resulted in clinically significant trough blood pressure reductions (nifedipine GITS -10.1/-8.9 mmHg, nifedipine retard -7.5/-8.2 mmHg). The study demonstrated that nifedipine GITS was 'at least equivalent' to nifedipine retard in the reduction of trough diastolic blood pressure (one-sided lower 95% confidence limit, -1.2 mmHg). The overall incidence of adverse events (nifedipine GITS 25.5%, nifedipine retard 34.0%), as well as the incidences of headache (nifedipine GITS 8.5%, nifedipine retard 12.8%) and peripheral oedema (nifedipine GITS 2.1%, nifedipine retard 8.5%), was higher with nifedipine retard compared to nifedipine GITS. Nifedipine GITS 20 mg once daily is 'at least equivalent' to nifedipine retard 10 mg twice daily in patients with mild to moderate hypertension, as well as being better tolerated.
机译：在49位轻度至中度高血压患者中，进行了每日一次一次的硝苯地平GITS和每天两次两次的硝苯地平缓释10 mg的多中心，随机，双盲交叉比较。两种治疗均导致临床上显着降低谷底血压（硝苯地平GITS -10.1 / -8.9 mmHg，硝苯地平延迟-7.5 / -8.2 mmHg）。研究表明，硝苯地平GITS在降低谷类舒张压方面（至少降低了95％的置信度下限-1.2 mmHg）与“硝苯地平延迟”至少“相等”。不良事件的整体发生率（硝苯地平GITS 25.5％，硝苯地平延迟34.0％），以及头痛（硝苯地平GITS 8.5％，硝苯地平延迟12.8％）和周围水肿的发生率（硝苯地平GITS 2.1％，硝苯地平延迟8.5％）与硝苯地平GITS相比，硝苯地平延缓给药的，更高。对于轻度至中度高血压患者，每天两次服用硝苯地平GITS 20 mg“至少相当于”每天两次两次硝苯地平延迟10 mg，并且耐受性更好。

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