Cyclophosphamide as disease-modifying therapy for scleroderma: pros and cons

C Chighizola; VH Ong; CP Denton

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Cyclophosphamide as disease-modifying therapy for scleroderma: pros and cons

机译：环磷酰胺作为硬皮病的疾病缓解疗法：利弊

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Cyclophosphamide is widely used to treat severe manifestations of numerous autoimmune rheumatic diseases including systemic sclerosis. Based on recent data, immunological and inflammatory activation remain the primary therapeutic targets in systemic sclerosis. Other effective therapies targeting the f ibrotic mechanisms have not been developed despite the increased understanding of the key pathogenic pathways. The two pivotal studies of cyclophosphamide in scleroderma-associated interstitial lung disease have rejuvenated interest in this chemotherapeutic agent in this disease. Although the studies suggest that the benefit is modest, identification of appropriate patients is central to management to harness its maximal potential clinical efficacy. This article provides a timely evaluation of the benefits and drawbacks of cyclophosphamide in systemic sclerosis.

机译：环磷酰胺被广泛用于治疗包括系统性硬化症在内的多种自身免疫性风湿性疾病的严重表现。根据最近的数据，免疫和炎症激活仍然是系统性硬化症的主要治疗目标。尽管人们对关键的致病途径有了更多的了解，但尚未开发出针对纤维化机制的其他有效疗法。在硬皮病相关的间质性肺疾病中环磷酰胺的两项关键研究使人们对该疾病的这种化学治疗剂产生了兴趣。尽管研究表明，获益不大，但确定合适的患者对于控制其最大潜在临床疗效至关重要。本文及时评估了环磷酰胺在全身性硬化中的利弊。

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《International journal of clinical rheumatology.》 |2011年第2期|共12页
作者
C Chighizola; VH Ong; CP Denton;
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正文语种 eng
中图分类全身性疾病;
关键词
cyclophosphamide; hemorrhagic cystitis; interstitial lung disease; malignancy; systemic sclerosis;

机译：环磷酰胺;出血性膀胱炎;间质性肺疾病;恶性肿瘤;系统性硬化;

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1. Cyclophosphamide as disease-modifying therapy for scleroderma: pros and cons [J] . C Chighizola, VH Ong, CP Denton International journal of clinical rheumatology. . 2011,第2期

机译：环磷酰胺作为硬皮病的疾病缓解疗法：利弊
2. A novel therapeutic approach to the treatment of scleroderma-associated pulmonary complications: safety and efficacy of combination therapy with imatinib and cyclophosphamide [J] . I. Sabnani1 M. J. Zucker1 E. D. Rosenstein2 D. A. Baran1 L. H. Arroyo1 P. Tsang1 M. Zubair1 and V. Rivera1 Rheumatology . 2009,第1期

机译：一种新的治疗硬皮病相关肺部并发症的方法：伊马替尼和环磷酰胺联合治疗的安全性和有效性
3. A novel therapeutic approach to the treatment of scleroderma-associated pulmonary complications: safety and efficacy of combination therapy with imatinib and cyclophosphamide. [J] . Sabnani I, Zucker MJ, Rosenstein ED, Rheumatology . 2009,第1期

机译：一种新的治疗硬皮病相关肺部并发症的方法：伊马替尼和环磷酰胺联合治疗的安全性和有效性。
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机译：激光光调节在5种氟尿嘧啶+阿霉素+环磷酰胺-FAC化疗方案中与环磷酰胺，甲氨蝶呤，5-氟尿嘧啶-CMF相关的口腔黏膜演变中的应用
5. Pros and cons of suppressive antibiotic therapy in the treatment of recurrent urinary tract infections in the adult female [D] . Hendricks, Mary Beth (Martin) 2009

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6. Treatment With Mycophenolate and Cyclophosphamide Leads to Clinically Meaningful Improvements in Patient‐Reported Outcomes in Scleroderma Lung Disease: Results of Scleroderma Lung Study II [O] . Elizabeth R. Volkmann, Donald P. Tashkin, Holly LeClair, 2020

机译：霉酚酸酯和环磷酰胺的治疗导致硬皮病肺病患者报告的结果临床意义上的改善：硬皮病肺研究II
7. Treatment of Scleroderma-Interstitial Lung Disease With Cyclophosphamide Is Associated With Less Progressive Fibrosis on Serial Thoracic High-Resolution CT Scan Than Placebo: Findings From the Scleroderma Lung Study [O] . Goldin, Jonathan, Elashoff, Robert, Kim, Hyun J., 2009

机译：环磷酰胺治疗硬皮病-间质性肺疾病与连续性胸部高分辨率CT扫描相比安慰剂的进展性纤维化程度更低：硬皮病肺研究的结果

Cyclophosphamide as disease-modifying therapy for scleroderma: pros and cons

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