A population-based, nested case-control study involving 205,466 women has demonstrated an increased risk of atypical (subtrochanteric or femoral shaft) fractures in older women taking bisphosphonates for 5 years or more. The study analyzed a cohort of women 68 years of age or older from Ontario, Canada, who started oral bisphospho-nate treatment between 1 April 2002 and 31 March 2008. Case patients, defined as women hospitalized with an atypical fracture, were matched to up to five control participants without such fractures and follow-up of participants continued until 31 March 2009.
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