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首页> 外文期刊>British journal of ophthalmology >Periocular carboplatin for retinoblastoma: Long-term report (12 years) on efficacy and toxicity
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Periocular carboplatin for retinoblastoma: Long-term report (12 years) on efficacy and toxicity

机译：眼周卡铂治疗视网膜母细胞瘤：疗效和毒性的长期报告（12年）

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Aim: To report the experience of the authors with efficacy and toxicity of periocular chemotherapy over a 12-year period. Methods: 102 periocular injections of 2 cc (10 mg of carboplatin/1 cc) were given every 4-6 weeks in 33 eyes of 29 patients. Patient's data were reviewed retrospectively. Results: Thirty-three eyes were followed for 7-148 months following initiation of periocular injections, and 13 (39%) have avoided enucleation. There were two cases of second malignancy resulting in one death and one survivor, two survivors of metastatic disease, and two survivors of orbital recurrence. Twenty eyes were enucleated for disease progression at a mean time of 15 months postinitiation of periocular carboplatin (POC). The KaplaneMeier estimate of eye survival at 36 months is 36%. Eleven of the 13 salvaged eyes received concurrent treatment with chemotherapy (n=4, 30%), external beam radiation and chemotherapy in (n=6, 46%), or brachytherapy (n=1, 8%). Two of the salvaged eyes (16%) were treated with POC alone. Orbital swelling occurred in 14/33 (42%) eyes. There were no symptomatic motility disorders. One severe toxicity reaction resulted in acute loss of vision, down to light perception, which failed to recover and one eye had progression of optic nerve pallor. Conclusions: This paper demonstrates that POC has limited short-term and long-term systemic toxicity and most of the ocular complications were acute, not delayed. Only two select cases showed long-term complete responses to POC alone and the data do not support the use as monotherapy, although where it was used in combination with other modalities, 39% of the eyes were saved.
机译：目的：报告作者在十二年期间在眼周化疗的功效和毒性方面的经验。方法：29例患者的33只眼每4-6周进行102次眼周注射2 cc（10 mg卡铂/ 1 cc）。回顾性分析患者的数据。结果：在开始眼周注射后，对33眼进行了7-148个月的随访，其中13眼（39％）避免了摘除眼球。有2例第二次恶性肿瘤导致1例死亡和1例幸存者，2例转移性疾病幸存者和2例眼眶复发患者。在眼周卡铂（POC）启动后的15个月的平均时间内摘除20只眼的疾病进展。 KaplaneMeier估计的36个月眼存活率为36％。在13例打捞的眼睛中，有11例同时接受了化疗（n = 4，30％），外照射和化疗（n = 6，46％）或近距离放射疗法（n = 1，8％）。两只挽救的眼睛（占16％）仅接受POC治疗。 14/33（42％）眼眶发生肿胀。没有症状性运动障碍。一项严重的毒性反应导致严重的视力丧失，直至光知觉，无法恢复，一只眼睛的视神经苍白。结论：本文证明POC短期和长期全身毒性有限，大多数眼部并发症是急性的，而不是延迟的。只有两个选定的病例显示出对POC的长期完全反应，并且数据不支持单药治疗，尽管在与其他方式联合使用的情况下，保留了39％的眼睛。

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