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首页> 外文期刊>International journal of colorectal disease. >Increasing anastomosis safety and preventing abdominal adhesion formation by the use of polypeptides in the rat.
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Increasing anastomosis safety and preventing abdominal adhesion formation by the use of polypeptides in the rat.

机译：通过在大鼠中使用多肽来提高吻合的安全性并防止腹部粘连的形成。

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BACKGROUND AND AIMS: Postoperative adhesions can potentially be reduced using different anti-adhesive agents, though these drugs tend to compromise healing of an intestinal anastomosis. No method that significantly increases anastomosis safety is known at present. The aim of the study was to develop a concept of preventing postoperative adhesions using differently charged bioactive polypeptides, also considering healing and safety of an intestinal anastomosis. METHODS: An ileocolic anastomosis was performed under both "clean" and "septic" conditions in the rat. The treatment group received intraperitoneal poly-L: -lysine and poly-L: -glutamate, while controls received sodium chloride. Abdominal adhesions, anastomosis leakage and burst pressure were analysed after 1, 3, 5 and 7 days in the clean anastomosis model and after 7 days in the septic model. RESULTS: A significant decrease (p<0.01) in the amount of adhesions was seen in animals treated with polypeptides after 1, 3 and 5 days, while no difference was seen after 7 days. The anastomosis demonstrated a significantly higher burst pressure as evaluated at days 1 and 3 (p<0.05 and p<0.01, respectively) in the polypeptide-treated animals, while no difference was seen between the groups at day 5 or 7. CONCLUSION: The use of differently charged polypeptides administered intraperitoneally after surgery resulted in a significant decrease in the extent of postoperative adhesions. Furthermore, an increase in intestinal anastomosis safety, based on improved burst pressure during the first 3 days, i.e. the critical period during the healing process, was noted. No adverse effects were seen in surgery during septic conditions.
机译：背景与目的：尽管这些药物往往会损害肠吻合的愈合，但使用不同的抗粘剂可能会减少术后粘连。目前尚无可显着提高吻合术安全性的方法。该研究的目的是开发一种概念，即使用带不同电荷的生物活性多肽预防术后粘连，同时考虑肠道吻合的愈合和安全性。方法：在大鼠的“清洁”和“脓性”条件下进行回盲吻合术。治疗组接受腹膜内聚-L：-赖氨酸和聚-L：-谷氨酸，而对照组接受氯化钠。在干净的吻合模型中的1、3、5和7天后以及在脓毒症模型中的7天后，分析腹部的粘连，吻合术的渗漏和破裂压力。结果：在用多肽处理的动物中，第1、3和5天后粘附量显着降低（p <0.01），而在7天后未见差异。如在多肽处理的动物中，在第1天和第3天评估时，吻合显示出显着更高的破裂压力（分别为p <0.05和p <0.01），而在第5天或第7天两组之间没有发现差异。手术后腹膜内施用不同电荷的多肽的使用导致术后粘连程度的显着降低。此外，注意到在前三天即愈合过程中的关键时期，由于破裂压力提高，肠吻合安全性提高。在败血症状态下的手术中未见不良反应。

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