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首页> 外文期刊>British journal of ophthalmology >Visual outcome in infants born to drug-misusing mothers prescribed methadone in pregnancy
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Visual outcome in infants born to drug-misusing mothers prescribed methadone in pregnancy

机译：药物滥用母亲在怀孕期间开具美沙酮的婴儿的视觉结果

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Background Flash visual evoked potentials (VEPs) were abnormal in a cohort of 100 neonates exposed to maintenance methadone in utero. This prospective cohort study now describes clinical visual and electrophysiological outcomes at 6 months. Methods Visual assessment included modified Atkinson test battery; strabismus, nystagmus, reduced visual acuity, delayed visual maturation or refractive error (≥3 dioptres) defined a fail. Pattern-onset VEPs were recorded to 1200, 600 and 150 checks. Results 81 drug-exposed and 26 comparison infants (79% and 52% of the original cohorts) were assessed at a median age of 27 weeks (range 26-30). 90% of drug-exposed infants had been additionally exposed to illicit drugs and 41% to excess alcohol in utero. 40% of the drug-exposed cohort failed clinical visual assessment: the relative risk of abnormal assessment was 5.1 (95% CI 1.3 to 20; p=0.02). Nystagmus was particularly common. VEP peak times were slower and amplitudes smaller in drug-exposed infants, of whom 70% had one or more abnormal VEP parameter. Abnormal visual outcome at 6 months was not associated with the pattern of additional drug exposure or a history of neonatal abstinence. Conclusions Abnormal visual electrophysiology in infants born to drug-misusing mothers prescribed maintenance methadone persists to 6 months of age, and is associated with abnormal clinical visual assessment.
机译：背景闪光的视觉诱发电位（VEPs）在子宫内维持美沙酮维持治疗的100名新生儿队列中是异常的。现在，这项前瞻性队列研究描述了6个月时的临床视觉和电生理结果。方法视觉评估包括改良的Atkinson测试电池;斜视，眼球震颤，视力下降，视力发育迟缓或屈光不正（屈光度≥3）定义为失败。模式发作的VEP被记录为1200、600和150次检查。结果对81名接受过药物治疗的婴儿和26名比较婴儿（原始队列的79％和52％）进行了评估，他们的中位年龄为27周（范围26-30）。 90％的药物接触婴儿另外在子宫内接触了非法药物，而41％的婴儿在子宫内接触了过量的酒精。接受药物治疗的队列中有40％的临床视觉评估失败：异常评估的相对风险为5.1（95％CI为1.3至20; p = 0.02）。眼球震颤特别常见。在接受药物治疗的婴儿中，VEP峰值时间较慢，幅度较小，其中70％的婴儿具有一项或多项异常VEP参数。 6个月时的视觉结果异常与额外的药物暴露模式或新生儿戒酒史无关。结论滥用药物的母亲开具维持美沙酮的婴儿视觉视觉生理异常持续至6个月大，并与临床视觉评估异常有关。

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