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首页> 外文期刊>British journal of ophthalmology >Plasma endothelin-1 concentrations in patients with retinal vein occlusions (see comments)
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Plasma endothelin-1 concentrations in patients with retinal vein occlusions (see comments)

机译：视网膜静脉阻塞患者血浆内皮素-1的浓度（见评论）

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摘要

AIMS: To investigate whether plasma levels of endothelin-1 (ET-1), a potent vasoconstricting peptide that is crucial in regulating retinal blood flow, were elevated in patients with retinal vein occlusion (RVO). METHODS: ET-1 plasma concentrations were determined by radioimmunoassays in a double blind fashion in a group of 18 selected patients with RVO, in 20 healthy age matched non-smoking, normoglycaemic, normotensive control subjects, and in 15 patients with uncomplicated essential hypertension in the same age range. RESULTS: Patients with RVO had significantly increased ET-1 plasma levels (14.22 (SD 4.6) pg/ml) compared with both normal subjects (7.90 (1.6) pg/ml; p < 0.05) and hypertensive patients (8.50 (2.9) pg/ml; p < 0.05). The highest concentrations of circulating ET-1 were found in patients with RVO of the ischaemic type (16.97 (3.5) pg/ml; p < 0.01; n = 7). Systemic hypertension alone did not account for the observed increase in plasma ET-1 concentrations. CONCLUSIONS: These findings raise the possibility that the increased circulating ET-1 levels in patients with RVO may be a marker of the occlusive event, thereby suggesting that ET-1 homeostasis may be relevant to RVO pathogenesis and retinal ischaemic manifestations.
机译：目的：研究视网膜血管闭塞（RVO）患者血浆内皮素-1（ET-1）的水平是否升高，这是一种在调节视网膜血流中至关重要的有效血管收缩肽。方法：采用放射免疫法以双盲方式测定了18例RVO患者，20例健康年龄匹配的非吸烟，正常血糖，血压正常对照者和15例单纯高血压的患者的ET-1血浆浓度。相同的年龄范围。结果：与正常受试者（7.90（1.6）pg / ml; p <0.05）和高血压患者（8.50（2.9）pg）相比，RVO患者的ET-1血浆水平显着升高（14.22（SD 4.6）pg / ml）。 /ml;p＜0.05）。缺血型RVO患者的循环ET-1浓度最高（16.97（3.5）pg / ml; p <0.01; n = 7）。仅全身性高血压并不能说明观察到的血浆ET-1浓度增加。结论：这些发现增加了RVO患者循环中ET-1水平升高可能是闭塞事件的标志，从而表明ET-1稳态可能与RVO发病机制和视网膜缺血表现有关。

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