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首页> 外文期刊>International Journal of Epidemiology: Official Journal of the International Epidemiological Association >Regional serum cholesterol differences in Belgium: do genetically determined cardiovascular risk factors contribute?
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Regional serum cholesterol differences in Belgium: do genetically determined cardiovascular risk factors contribute?

机译：比利时的区域血清胆固醇差异：遗传学确定的心血管危险因素是否起作用？

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BACKGROUND: Differences in serum lipid distribution and mortality from ischaemic heart disease have repeatedly been reported between Belgian northerners and southerners. We investigated whether serum lipoprotein(a) (Lp(a)) and apolipoprotein (apo) E polymorphism were involved. METHODS: Fasting serum lipids, apo A-I and B, and Lp(a) levels were examined in randomly selected, 20-39 year old Belgian males and females from the north (Flanders) and the south (Wallonia) of Belgium (N = 900). Apo E phenotype distribution was investigated in random subsamples from either region (N = 249). RESULTS: Mean serum cholesterol, low density lipoprotein cholesterol (LDL-c), apo B and triglyceride levels were higher in Walloons compared to Flemings within each gender, the difference being significant in 30-39 year old males. Average high density lipoprotein cholesterol and apo A-I levels were significantly lower in 30-39 year old male southerners, compared to their northern counterparts. Median Lp(a) was 67 mg/l in northerners and 75 mg/l in southerners (NS). The apo E phenotype distribution was similar in both regions (chi2 = 7.213; d.f. = 5; P = 0.2053), whereas the average effects of the apo E alleles differed between the regions. In southerners the epsilon4 effect upon adjusted apo B and LDL-c levels was approximately+12% and the epsilon2 effect was approximately-15%; in northerners the epsilon4 and epsilon2 effects were approximately+5% and approximately-25%, respectively. The apo E polymorphism did not affect serum Lp(a) levels. CONCLUSIONS: Regional cholesterol differences between Flemings and Walloons cannot be explained by differences in serum Lp(a) or apo E phenotype distribution. The less favourable epsilon2 and epsilon4 effects in southerners compared to northerners reflect modulation of the apo E gene by particular environments.
机译：背景：比利时北方人和南方人之间反复报道了血清脂质分布和缺血性心脏病死亡率的差异。我们调查了血清脂蛋白（a）（Lp（a））和载脂蛋白（apo）E多态性是否参与。方法：从比利时北部（佛兰德斯）和南部（瓦洛尼亚）（N = 900）随机选择的20-39岁比利时男性和女性中，检查空腹血清脂质，apo AI和B以及Lp（a）的水平。 ）。在任一区域（N = 249）的随机子样本中研究了Apo E表型分布。结果：在瓦隆人中，平均性别的血清胆固醇，低密度脂蛋白胆固醇（LDL-c），载脂蛋白B和甘油三酸酯水平高于弗莱明斯，在30-39岁的男性中差异显着。与北部的同龄人相比，在30-39岁的男性南部人中，平均高密度脂蛋白胆固醇和apo A-I水平显着降低。北方人的Lp（a）中位数为67 mg / l，南方人（NS）的中位数Lp（a）为75 mg / l。两个区域的载脂蛋白E表型分布相似（chi2 = 7.213; d.f。= 5; P = 0.2053），而载脂蛋白E等位基因的平均效应在两个区域之间有所不同。在南方人中，在调整的载脂蛋白B和LDL-c水平下，ε4的作用约为+ 12％，ε2的作用约为-15％;在北方人中，epsilon4和epsilon2的作用分别为大约+ 5％和大约-25％。 Apo E多态性不影响血清Lp（a）水平。结论：弗莱明斯和瓦隆人之间的区域胆固醇差异不能通过血清Lp（a）或载脂蛋白E表型分布的差异来解释。与北方人相比，南方人对epsilon2和epsilon4的不利影响反映了特定环境对apo E基因的调节。

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