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首页> 外文期刊>International journal of developmental neuroscience: the official journal of the International Society for Developmental Neuroscience >Neurodevelopmental sequelae associated with gray and white matter changes and their cellular basis: A comparison between Autism Spectrum Disorder, ADHD and dyslexia
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Neurodevelopmental sequelae associated with gray and white matter changes and their cellular basis: A comparison between Autism Spectrum Disorder, ADHD and dyslexia

机译：与灰质和白质变化相关的神经发育后遗症及其细胞基础：自闭症谱系障碍，ADHD和阅读障碍的比较

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摘要

Many psychiatric diseases, such as major depression and schizophrenia, are accompanied by patterns of gray matter and white matter changes in the cortex that may be due to structural pathologies of synapses and their dendrites in the gray matter on the one hand and to pathologies in myelinating oligodendrocytes on the other. Here the possibility has been briefly examined that such a generalization might also hold for Autistic Spectrum Disorders (ASD). Evidence is presented that gray matter changes that accompany ASD may in fact reflect changes in synapses and subsequently of their dendrites, whereas those in the white matter reflect changes in myelination due to pathologies of oligodendrocytes. It is proposed that such structural pathologies during development provide a coherent biological model not only for the onset and course of ASD but also provide the basis for development and systematic evaluation of new treatment strategies. Crown Copyright (C) 2015 Published by Elsevier Ltd. on behalf of ISDN. All rights reserved.
机译：许多精神疾病，例如严重的抑郁症和精神分裂症，伴随着皮质中灰质和白质变化的模式，一方面可能是由于突触的结构病理及其在灰质中的树突以及髓鞘病变引起的。少突胶质细胞。在这里，已经简要检查了这种概括也可能适用于自闭症谱系障碍（ASD）的可能性。有证据表明，ASD伴随的灰质变化实际上可能反映了突触及其树突的变化，而白质变化反映了由于少突胶质细胞病变引起的髓鞘化变化。有人提出，这种在发展过程中的结构病理学不仅为自闭症的发作和病程提供了一个连贯的生物学模型，而且还为新的治疗策略的发展和系统评价提供了基础。 Crown版权所有（C）2015，由Elsevier Ltd.代表ISDN发布。版权所有。

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