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首页> 外文期刊>International journal of hyperthermia: The official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group >Blood flow and associated pathophysiology of uterine cervix cancers: Characterisation and relevance for localised hyperthermia
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Blood flow and associated pathophysiology of uterine cervix cancers: Characterisation and relevance for localised hyperthermia

机译：子宫颈癌的血流和相关病理生理学：局部热疗的特征和相关性

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摘要

Cervical cancers exhibit substantial intra- and inter-tumour heterogeneities in blood flow prior to treatment, reflecting similar variability in vascularisation. When clinically relevant hyperthermia is applied as an adjuvant to established treatment modalities, blood flow may change in non-predictable directions, extents and durations, indicating subsequent variability in heat dissipation and in flow-associated parameters of the tumour microenvironment. Before heating, locally advanced cervical cancers are mostly hypoxic, acidic, exhibit substrate and energy deprivation and show lactate accumulation, which is spatially and temporally heterogeneous. Additionally a relatively homogeneous interstitial hypertension is observed. Most probably, metabolic parameters of the hostile microenvironment are able to greatly modulate the thermosensitivity of cancer cells. Adequate information concerning changes upon heat treatment is not available so far. Due to this lack of proven data for cervical cancers upon heat treatment, clinical studies are urgently needed in order to judge the possible impact of blood flow and the above-mentioned microenvironmental parameters.
机译：子宫颈癌在治疗前在血流中表现出明显的肿瘤内和肿瘤间异质性，反映了相似的血管化变异性。当将临床相关的高温疗法作为已确立的治疗方式的佐剂时，血流可能会在不可预测的方向，程度和持续时间上发生变化，这表明随后的散热和肿瘤微环境的血流相关参数会发生变化。在加热之前，局部晚期宫颈癌大多为低氧，酸性，显示底物和能量缺乏以及乳酸累积，这在空间和时间上是不均匀的。另外，观察到相对均匀的间质性高血压。敌对微环境的代谢参数很可能能够极大地调节癌细胞的热敏感性。到目前为止，还没有足够的有关热处理变化的信息。由于缺乏治疗后宫颈癌的可靠数据，迫切需要临床研究，以判断血流和上述微环境参数的可能影响。

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