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首页> 外文期刊>International journal of hyperthermia: The official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group >In vivo change in ultrasonic backscattered energy with temperature in motion-compensated images.
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In vivo change in ultrasonic backscattered energy with temperature in motion-compensated images.

机译：运动补偿图像中超声反向散射能量随温度的体内变化。

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摘要

Ultrasound is an attractive modality for non-invasive imaging to monitor temperature of tumorous regions undergoing hyperthermia therapy. Previously, we predicted monotonic changes in backscattered energy (CBE) of ultrasound with temperature for certain sub-wavelength scatterers. We also measured CBE values similar to our predictions in bovine liver, turkey breast muscle, and pork rib muscle in both 1D and 2D in in vitro studies. To corroborate those results in perfused, living tissue, we measured CBE in both normal tissue and in implanted human tumors (HT29 colon cancer line) in 7 nude mice. Images were formed by a phased-array imager with a 7.5 MHz linear probe during homogeneous heating from 37 degrees to 45 degrees C in 0.5 degrees C steps and from body temperature to 43 degrees C during heterogeneous heating. We used cross-correlation as a similarity measure in RF signals to automatically track feature displacement as a function of temperature. Feature displacement was non-uniform with a maximum value of 1 mm across all specimens during homogeneous heating, and 0.2 mm during heterogeneous heating. Envelopes of image regions, compensated for non-rigid motion, were found with the Hilbert transform then smoothed with a 3 x 3 running average filter before forming the backscattered energy at each pixel. Means of both the positive and negative changes in the BE images were evaluated. CBE was monotonic and accumulated to 4-5 dB during homogeneous heating to 45 degrees C and 3-4 dB during heterogenous heating to 43 degrees C. These results are consistent with our previous in vitro measurements and support the use of CBE for temperature estimation in vivo during hyperthermia.
机译：超声是用于非侵入性成像以监视正在进行热疗的肿瘤区域的温度的一种有吸引力的方式。以前，我们预测了某些亚波长散射体的超声后向散射能量（CBE）随温度的单调变化。在体外研究中，我们还在1D和2D中测得的CBE值与我们在牛肝，火鸡胸肌和猪肋骨肌中的预测相似。为了证实在灌注的活组织中的结果，我们在7只裸鼠中的正常组织和植入的人类肿瘤（HT29结肠癌细胞系）中都测量了CBE。图像是由相控阵成像仪和7.5 MHz线性探头在从37摄氏度到45摄氏度以0.5摄氏度的步幅均匀加热以及从体温到43摄氏度的均匀加热过程中形成的。我们使用互相关作为RF信号中的相似性度量，以自动跟踪随温度变化的特征位移。特征位移是不均匀的，在均匀加热期间所有样本的最大值均为1 mm，在异质加热期间最大值为0.2 mm。用希尔伯特变换找到补偿了非刚性运动的图像区域的包络，然后在每个像素处形成反向散射能量之前，用3 x 3的运行平均滤波器对其进行平滑处理。评估了BE图像中正负变化的平均值。 CBE是单调的，在均匀加热到45摄氏度时累积到4-5 dB，在异质加热到43摄氏度时累积到3-4 dB。这些结果与我们之前的体外测量结果一致，并支持将CBE用于温度估算体温过高。

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