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首页> 外文期刊>Biochemical Genetics >Evaluation of Local CYP17A1 and CYP19A1 Expression Levels as Prognostic Factors in Postmenopausal Invasive Ductal Breast Cancer Cases
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Evaluation of Local CYP17A1 and CYP19A1 Expression Levels as Prognostic Factors in Postmenopausal Invasive Ductal Breast Cancer Cases

机译：评价局部CYP17A1和CYP19A1表达水平作为绝经后浸润性导管癌病例的预后因素

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There is growing attention focused on local estrogen production in the breast tissue and its possible role in breast cancer initiation and progression. Understanding the underlying mechanisms for estrogen synthesis and the microenvironment consisting of tumor and its surrounding adipose tissue might open new avenues in breast cancer prevention, prognosis and treatment. In order to obtain insight, we compared peritumoral and tumor tissue expressions of CYP17A1 and CYP19A1 genes, which play an important role in estrogen biosynthesis. The paired tissue samples of 20 postmenopausal ER+/PR+ patients diagnosed with invasive ductal breast cancer were studied. In addition, 12 breast tissue samples obtained from premenopausal women without a history of breast cancer were also investigated as representative of normal conditions. Peritumoral adipose tissues expressed CYP19A1 approximately threefold higher than tumor itself (p = 0.001). A nonsignificant trend toward low expression of CYP17A1 was observed in peritumoral compared to tumor tissue (p = 0.687). Clinicopathological parameters and patient characteristics which are accepted as risk factors for breast cancer were also associated with individual and combined expressions of CYP17A1 and CYP19A1. This study offers that evaluation of CYP17A1 and CYP19A1 local expression levels might be useful for deciding on personalized treatment approaches and more accurate diagnosis, when evaluated together with several clinicopathological and disease risk factors. Considering the key role of these CYPs in estrogen synthesis, determining their expression levels may be useful as a postdiagnostic marker and for choosing the right treatment method in addition to the conventional approach.
机译：人们越来越关注乳房组织中的局部雌激素产生及其在乳腺癌的发生和发展中的可能作用。了解雌激素合成的基本机制以及由肿瘤及其周围脂肪组织组成的微环境可能为乳腺癌的预防，预后和治疗开辟新的途径。为了获得见解，我们比较了CYP17A1和CYP19A1基因在肿瘤周围和肿瘤组织中的表达，它们在雌激素的生物合成中起着重要的作用。研究了20例经诊断为浸润性导管癌的绝经后ER + / PR +患者的配对组织样本。此外，还调查了从绝经前妇女中无乳腺癌史的12个乳腺组织样本，作为正常情况的代表。 CYP19A1的表达是肿瘤周围组织的三倍（p = 0.001）。与肿瘤组织相比，在肿瘤周围观察到CYP17A1低表达的非显着趋势（p = 0.687）。被认为是乳腺癌危险因素的临床病理参数和患者特征也与CYP17A1和CYP19A1的单独和联合表达有关。这项研究提供了CYP17A1和CYP19A1局部表达水平的评估与几种临床病理和疾病风险因素一起评估时，可能有助于决定个性化治疗方法和更准确的诊断。考虑到这些CYP在雌激素合成中的关键作用，确定它们的表达水平可能是诊断后的标志，并且除了常规方法外，还可用于选择正确的治疗方法。

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