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首页> 外文期刊>Biochemical Genetics >BAFF Expression is Modulated by Female Hormones in Human Immune Cells
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BAFF Expression is Modulated by Female Hormones in Human Immune Cells

机译：BAFF表达受人类免疫细胞中雌性激素的调节。

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Among several autoimmune diseases, one of the main risk factors is the female gender, and much consideration has been given to the involvement of female hormones in their etiology. B-cell activating factor (BAFF) is a key factor in survival and maturation of B cells and is overexpressed in several autoimmune patients although the mechanism behind this feature is unclear. In murine models, BAFF expression could be upregulated by exogenous estrogen treatment in splenocytes; however, no evidence of this relationship was available in humans. Here, leukocytes from healthy male and female individuals were collected and cultivated in the presence or absence of estrogen or progesterone. BAFF gene expression was accessed by quantitative PCR and compared between treated and untreated group of cells. In the presence of estrogen, BAFF expression was upregulated by more than 5 times in both genders. When exposed to progesterone, the female-originated cells showed increased expression, while the cells of male origin a significant downregulation of BAFF. Our results suggest that female hormones can modulate the expression of BAFF, a key cytokine in autoimmune pathways, in human immune cells. These data might contribute to the understanding of the etiology as well as the gender bias featured by several autoimmune disorders.
机译：在几种自身免疫性疾病中，主要的危险因素之一是女性，并且已经充分考虑了女性荷尔蒙的病因。 B细胞活化因子（BAFF）是B细胞存活和成熟的关键因素，在一些自身免疫性患者中过表达，尽管该功能背后的机制尚不清楚。在鼠模型中，脾细胞中外源性雌激素处理可上调BAFF表达。然而，在人类中没有这种关系的证据。在这里，在有或没有雌激素或孕激素的情况下，收集健康男性和女性个体的白细胞并进行培养。通过定量PCR获得BAFF基因表达，并在处理和未处理的细胞组之间进行比较。在雌激素的存在下，男女BAFF表达上调了5倍以上。当暴露于孕酮时，雌性起源的细胞显示出增加的表达，而雄性起源的细胞则显着下调了BAFF。我们的结果表明，女性荷尔蒙可以调节人体免疫细胞中自身免疫途径中的关键细胞因子BAFF的表达。这些数据可能有助于了解病因以及几种自身免疫性疾病的性别偏见。

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